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    MAP3K7CL MAP3K7 C-terminal like [ Homo sapiens (human) ]

    Gene ID: 56911, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MAP3K7CLprovided by HGNC
    Official Full Name
    MAP3K7 C-terminal likeprovided by HGNC
    Primary source
    HGNC:HGNC:16457
    See related
    Ensembl:ENSG00000156265 MIM:611110; AllianceGenome:HGNC:16457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAKL; TAK1L; TAKL-1; TAKL-2; TAKL-4; C21orf7; HC21ORF7
    Summary
    Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart (RPKM 4.1), prostate (RPKM 2.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    21q21.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (29077114..29175887)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (27440554..27542501)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (30449435..30548208)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18328 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:30416252-30416450 Neighboring gene ubiquitin specific peptidase 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18330 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:30445041-30445952 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:30445953-30446864 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:30447741-30448940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18333 Neighboring gene chaperonin containing TCP1 subunit 8 Neighboring gene Sharpr-MPRA regulatory region 4059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13237 Neighboring gene NANOG hESC enhancer GRCh37_chr21:30506062-30506608 Neighboring gene ribosomal protein L12 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 14833 Neighboring gene uncharacterized LOC105372767 Neighboring gene small nucleolar RNA U3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18341 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:30568347-30569546 Neighboring gene long intergenic non-protein coding RNA 189 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel human TGF-beta activated kinase-like gene. Li J, et al. Biochem Genet, 2004 Apr. PMID 15168726
    2. Genome-wide identification of lncRNAs and mRNAs differentially expressed in human vascular smooth muscle cells stimulated by high phosphorus. Bao S, et al. Ren Fail, 2020 Nov. PMID 32401115, Free PMC Article
    3. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. Reymond A, et al. Genomics, 2001 Nov. PMID 11707072
    4. Genome-wide association scan of dental caries in the permanent dentition. Wang X, et al. BMC Oral Health, 2012 Dec 21. PMID 23259602, Free PMC Article
    5. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genome-wide identification of lncRNAs and mRNAs differentially expressed in human vascular smooth muscle cells stimulated by high phosphorus.
      Title: Genome-wide identification of lncRNAs and mRNAs differentially expressed in human vascular smooth muscle cells stimulated by high phosphorus.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association scan of dental caries in the permanent dentition.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    MAP3K7 C-terminal-like protein
    Names
    TAK1-like protein 1
    TAK1-like protein 2
    TAK1-like protein 4
    TGF-beta activated kinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286617.2 → NP_001273546.1  MAP3K7 C-terminal-like protein isoform 2

      See identical proteins and their annotated locations for NP_001273546.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks 2 exons in the 5' region and contains 2 additional exons, which result in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
      Source sequence(s)
      AF129075, AF269162, EF219157
      Consensus CDS
      CCDS68182.1
      UniProtKB/Swiss-Prot
      D3DSE0, P57077, Q8TCL9
      UniProtKB/TrEMBL
      B0EVZ8
      Related
      ENSP00000382817.2, ENST00000399935.6
      Conserved Domains (1) summary
      TIGR04211
      Location:39 → 142
      SH3_and_anchor; SH3 domain protein

    2. NM_001286618.2 → NP_001273547.1  MAP3K7 C-terminal-like protein isoform 2

      See identical proteins and their annotated locations for NP_001273547.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks 2 exons in the 5' region and contains an additional exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
      Source sequence(s)
      AF129075, AF269163, EF219157
      Consensus CDS
      CCDS68182.1
      UniProtKB/Swiss-Prot
      D3DSE0, P57077, Q8TCL9
      UniProtKB/TrEMBL
      B0EVZ8
      Related
      ENSP00000382816.1, ENST00000399934.5
      Conserved Domains (1) summary
      TIGR04211
      Location:39 → 142
      SH3_and_anchor; SH3 domain protein

    3. NM_001286619.2 → NP_001273548.1  MAP3K7 C-terminal-like protein isoform 2

      See identical proteins and their annotated locations for NP_001273548.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' end and contains 3 additional exons, which result in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
      Source sequence(s)
      AF269162, AK122780, AK294287, BG566433
      Consensus CDS
      CCDS68182.1
      UniProtKB/Swiss-Prot
      D3DSE0, P57077, Q8TCL9
      UniProtKB/TrEMBL
      B0EVZ8
      Related
      ENSP00000345777.4, ENST00000339024.8
      Conserved Domains (1) summary
      TIGR04211
      Location:39 → 142
      SH3_and_anchor; SH3 domain protein

    4. NM_001286620.2 → NP_001273549.1  MAP3K7 C-terminal-like protein isoform 2

      See identical proteins and their annotated locations for NP_001273549.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains alternate 5' end exons that result in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a distinct N-terminus compared to isoform 1. Variants 3-6 encode the same isoform.
      Source sequence(s)
      AF269161, BC008567
      Consensus CDS
      CCDS68182.1
      UniProtKB/Swiss-Prot
      D3DSE0, P57077, Q8TCL9
      UniProtKB/TrEMBL
      B0EVZ8
      Related
      ENSP00000382812.1, ENST00000399928.6
      Conserved Domains (1) summary
      TIGR04211
      Location:39 → 142
      SH3_and_anchor; SH3 domain protein

    5. NM_001286622.2 → NP_001273551.1  MAP3K7 C-terminal-like protein isoform 3

      See identical proteins and their annotated locations for NP_001273551.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks 2 exons in the 5' region and contains an additional exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (3) has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AF129075, AF269161, AK294287, EF219157
      Consensus CDS
      CCDS74775.1
      UniProtKB/TrEMBL
      B4DFW0
      Related
      ENSP00000437846.1, ENST00000545939.5
      Conserved Domains (1) summary
      cl09232
      Location:54 → 124
      YqaJ; YqaJ-like viral recombinase domain

    6. NM_001286623.2 → NP_001273552.1  MAP3K7 C-terminal-like protein isoform 4

      See identical proteins and their annotated locations for NP_001273552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks a non-coding exon in the 5' region and contains an alternate 3' terminal exon compared to variant 1. The resulting shorter isoform (4) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF129075, EF219157
      UniProtKB/TrEMBL
      B0EVZ6
      Related
      ENSP00000518225.1, ENST00000710354.1

    7. NM_001286624.2 → NP_001273553.1  MAP3K7 C-terminal-like protein isoform 5

      See identical proteins and their annotated locations for NP_001273553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks many exons from the 5' and mid region and contains an alternate 5' terminal exon, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The resulting isoform (5) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AF269161, AK309998, BI911525
      UniProtKB/TrEMBL
      B0EVZ7

    8. NM_001286634.2 → NP_001273563.1  MAP3K7 C-terminal-like protein isoform 1

      See identical proteins and their annotated locations for NP_001273563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks 2 exons in the 5' non-coding region compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AF129075, AF269161, EF219157
      Consensus CDS
      CCDS13584.1
      UniProtKB/Swiss-Prot
      P57077
      UniProtKB/TrEMBL
      B0EVZ6
      Related
      ENSP00000343212.4, ENST00000341618.8
      Conserved Domains (1) summary
      TIGR04211
      Location:118 → 242
      SH3_and_anchor; SH3 domain protein

    9. NM_001371369.1 → NP_001358298.1  MAP3K7 C-terminal-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AF124730, AF129075
      Consensus CDS
      CCDS13584.1
      Conserved Domains (1) summary
      TIGR04211
      Location:118 → 242
      SH3_and_anchor; SH3 domain protein

    10. NM_001371370.1 → NP_001358299.1  MAP3K7 C-terminal-like protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AF124730, AF129075
      Conserved Domains (1) summary
      TIGR04211
      Location:100 → 203
      SH3_and_anchor; SH3 domain protein

    11. NM_001371371.1 → NP_001358300.1  MAP3K7 C-terminal-like protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AF124730, AF129075, BP290461, DA021298
      Conserved Domains (1) summary
      TIGR04211
      Location:58 → 161
      SH3_and_anchor; SH3 domain protein

    12. NM_001371372.1 → NP_001358301.1  MAP3K7 C-terminal-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF124730, EF219159
      Consensus CDS
      CCDS68182.1
      UniProtKB/Swiss-Prot
      D3DSE0, P57077, Q8TCL9
      UniProtKB/TrEMBL
      B0EVZ8
      Related
      ENSP00000382809.1, ENST00000399925.5
      Conserved Domains (1) summary
      TIGR04211
      Location:39 → 142
      SH3_and_anchor; SH3 domain protein

    13. NM_001371373.1 → NP_001358302.1  MAP3K7 C-terminal-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF124730, AF129075, CB963708
      Consensus CDS
      CCDS68182.1
      UniProtKB/Swiss-Prot
      D3DSE0, P57077, Q8TCL9
      UniProtKB/TrEMBL
      B0EVZ8
      Related
      ENSP00000382810.1, ENST00000399926.5
      Conserved Domains (1) summary
      TIGR04211
      Location:39 → 142
      SH3_and_anchor; SH3 domain protein

    14. NM_001371374.1 → NP_001358303.1  MAP3K7 C-terminal-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AF124730, AF129075
      Consensus CDS
      CCDS68182.1
      UniProtKB/Swiss-Prot
      D3DSE0, P57077, Q8TCL9
      UniProtKB/TrEMBL
      B0EVZ8
      Conserved Domains (1) summary
      TIGR04211
      Location:39 → 142
      SH3_and_anchor; SH3 domain protein

    15. NM_001371376.1 → NP_001358305.1  MAP3K7 C-terminal-like protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AF124730, AF129075, EF219158
      UniProtKB/TrEMBL
      B0EVZ7

    16. NM_020152.4 → NP_064537.1  MAP3K7 C-terminal-like protein isoform 1

      See identical proteins and their annotated locations for NP_064537.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AF129075, AF269161, AY171599, EF219157
      Consensus CDS
      CCDS13584.1
      UniProtKB/Swiss-Prot
      P57077
      UniProtKB/TrEMBL
      B0EVZ6
      Related
      ENSP00000382828.2, ENST00000399947.6
      Conserved Domains (1) summary
      TIGR04211
      Location:118 → 242
      SH3_and_anchor; SH3 domain protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      29077114..29175887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440930.1 → XP_047296886.1  MAP3K7 C-terminal-like protein isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791813.1 Reference GRCh38.p14 PATCHES

      Range
      167848..269778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      27440554..27542501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57077.2 GenPept UniProtKB/Swiss-Prot:P57077

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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