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    Agtpbp1 ATP/GTP binding carboxypeptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290986, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Agtpbp1provided by RGD
    Official Full Name
    ATP/GTP binding carboxypeptidase 1provided by RGD
    Primary source
    RGD:1306307
    See related
    Ensembl:ENSRNOG00000018651 AllianceGenome:RGD:1306307
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metallocarboxypeptidase activity; tubulin binding activity; and zinc ion binding activity. Predicted to be involved in C-terminal protein deglutamylation and protein side chain deglutamylation. Predicted to be located in cytoplasm and nucleolus. Orthologous to human AGTPBP1 (ATP/GTP binding carboxypeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 362.7), Heart (RPKM 305.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17p14
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (5092108..5244414)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (5120540..5238874)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (5510009..5614416)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482661 Neighboring gene golgi membrane protein 1 Neighboring gene N(alpha)-acetyltransferase 35, NatC auxiliary subunit Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene uncharacterized LOC134482764 Neighboring gene uncharacterized LOC120097867

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. Shashi V, et al. EMBO J, 2018 Dec 3. PMID 30420557, Free PMC Article
    2. Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs). Rodríguez de la Vega Otazo M, et al. FASEB J, 2013 Feb. PMID 23085998
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in C-terminal protein deglutamylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within anterograde axonal transport of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within axonal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebellar Purkinje cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in eye photoreceptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in olfactory bulb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein side chain deglutamylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retrograde axonal transport of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic carboxypeptidase 1
    Names
    ATP/GTP binding protein 1
    NP_001099570.1
    XP_038951374.1
    XP_038951375.1
    XP_038951376.1
    XP_038951377.1
    XP_038951378.1
    XP_038951379.1
    XP_038951380.1
    XP_038951382.1
    XP_038951383.1
    XP_038951384.1
    XP_038951385.1
    XP_038951388.1
    XP_038951389.1
    XP_038951390.1
    XP_038951391.1
    XP_038951392.1
    XP_038951393.1
    XP_038951394.1
    XP_063132205.1
    XP_063132206.1
    XP_063132207.1
    XP_063132208.1
    XP_063132209.1
    XP_063132210.1
    XP_063132211.1
    XP_063132212.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106100.1 → NP_001099570.1  cytosolic carboxypeptidase 1

      See identical proteins and their annotated locations for NP_001099570.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474032
      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Related
      ENSRNOP00000025382.5, ENSRNOT00000025381.7
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      5092108..5244414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276136.1 → XP_063132206.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1

    2. XM_039095462.2 → XP_038951390.1  cytosolic carboxypeptidase 1 isoform X6

      Conserved Domains (2) summary
      cd06906
      Location:804 → 1074
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:647 → 781
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    3. XM_063276141.1 → XP_063132211.1  cytosolic carboxypeptidase 1 isoform X7

    4. XM_039095454.2 → XP_038951382.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    5. XM_063276137.1 → XP_063132207.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1

    6. XM_039095446.2 → XP_038951374.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    7. XM_039095457.2 → XP_038951385.1  cytosolic carboxypeptidase 1 isoform X2

      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    8. XM_039095464.2 → XP_038951392.1  cytosolic carboxypeptidase 1 isoform X8

      Conserved Domains (2) summary
      cd06906
      Location:862 → 1107
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    9. XM_039095465.2 → XP_038951393.1  cytosolic carboxypeptidase 1 isoform X9

      Conserved Domains (2) summary
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
      cl11393
      Location:862 → 1052
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    10. XM_039095460.2 → XP_038951388.1  cytosolic carboxypeptidase 1 isoform X4

      Conserved Domains (2) summary
      cd06906
      Location:833 → 1103
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:682 → 810
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    11. XM_039095451.2 → XP_038951379.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    12. XM_039095461.2 → XP_038951389.1  cytosolic carboxypeptidase 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JZV3
      Related
      ENSRNOP00000071198.2
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    13. XM_039095463.2 → XP_038951391.1  cytosolic carboxypeptidase 1 isoform X6

      Conserved Domains (2) summary
      cd06906
      Location:804 → 1074
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:647 → 781
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    14. XM_039095456.2 → XP_038951384.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    15. XM_039095448.2 → XP_038951376.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    16. XM_063276138.1 → XP_063132208.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1

    17. XM_039095447.2 → XP_038951375.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    18. XM_039095452.2 → XP_038951380.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    19. XM_039095455.2 → XP_038951383.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    20. XM_039095450.2 → XP_038951378.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    21. XM_039095449.2 → XP_038951377.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1
      Conserved Domains (2) summary
      cd06906
      Location:862 → 1132
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:705 → 839
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    22. XM_063276139.1 → XP_063132209.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1

    23. XM_063276135.1 → XP_063132205.1  cytosolic carboxypeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A6KAI4, G3V8G1

    24. XM_063276140.1 → XP_063132210.1  cytosolic carboxypeptidase 1 isoform X3

    25. XM_039095466.2 → XP_038951394.1  cytosolic carboxypeptidase 1 isoform X11

      Conserved Domains (2) summary
      cd06906
      Location:597 → 867
      M14_Nna1; Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases
      pfam18027
      Location:440 → 574
      Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

    26. XM_063276142.1 → XP_063132212.1  cytosolic carboxypeptidase 1 isoform X10

    RNA

    1. XR_010058817.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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