Ptprc protein tyrosine phosphatase, receptor type, C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprcprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Cprovided by RGD
Primary source: RGD:3451
See related: Ensembl:ENSRNOG00000000655 AllianceGenome:RGD:3451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lca; RT7; CD45; L-CA; T200
Summary: Enables protein tyrosine phosphatase activity. Involved in T cell receptor signaling pathway; regulation of gene expression; and response to gamma radiation. Located in cell surface. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 1284.0), Thymus (RPKM 1219.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (52147717..52259810, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (49596193..49708283, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (55061561..55174150, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The activity of SHP-1 was decreased after high partial pressure of oxygen treatment no matter what the duration was, while the activity of CD45 was decreased only after high partial pressure of oxygen that led to inhibition of lymphocyte function.
Title: [The state of SHP-1 and CD45 in lymphocyte under high partial pressure of oxygen].
CD22 binding to native CD45
Title: Comparison of CD22 binding to native CD45 and synthetic oligosaccharide.
the large CD45 ectodomain is required for optimal TCR signaling
Title: CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.
CD45 acts as a negative regulator of cytokine production.
Title: CD45 expression on rat acinar cells: involvement in pro-inflammatory cytokine production.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142448 (e-PCR)
- UniSTS:231695

D13Got34 (e-PCR)
- UniSTS:111905

RH94594 (e-PCR)
- UniSTS:119842

RH136913 (e-PCR)
- UniSTS:219002

D13Mit7 (e-PCR), detects polymorphism
- UniSTS:240255

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase regulator activity	TAS Traceable Author Statement more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine phosphatase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in bone marrow development	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling using intracellular calcium source	ISO Inferred from Sequence Orthology more info
involved_in cell cycle phase transition	ISO Inferred from Sequence Orthology more info
involved_in cellular response to extracellular stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell adhesion involved in substrate-bound cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane raft distribution	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antigen receptor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antigen receptor-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hematopoietic stem cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to aldosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in stem cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in bleb	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane microdomain	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase C

Names: T200 glycoprotein; leucocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; protein tyrosine phosphatase, receptor-type, c polypeptide

NP_001103357.1

EC 3.1.3.48

NP_001103358.1

EC 3.1.3.48

NP_001103359.1

EC 3.1.3.48

NP_001103360.1

EC 3.1.3.48

NP_612516.2

EC 3.1.3.48

XP_006249974.1

EC 3.1.3.48

XP_008767756.1

EC 3.1.3.48

XP_038946275.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109887.2 → NP_001103357.1 receptor-type tyrosine-protein phosphatase C isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two in-frame exons compared to variant 4. The resulting isoform (3) is shorter compared to isoform 4.

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6ICK1

Conserved Domains (5) summary

smart00194
Location:538 → 797

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:566 → 797

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:283 → 348

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:5 → 27

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:120 → 174

CD45; Leukocyte receptor CD45
NM_001109888.2 → NP_001103358.1 receptor-type tyrosine-protein phosphatase C isoform 5 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks two in-frame exons compared to variant 4. The resulting isoform (5) is shorter compared to isoform 4.

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8L2PZM8

Conserved Domains (5) summary

smart00194
Location:531 → 790

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:559 → 790

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:276 → 341

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:5 → 27

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:113 → 167

CD45; Leukocyte receptor CD45
NM_001109889.2 → NP_001103359.1 receptor-type tyrosine-protein phosphatase C isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two in-frame exons compared to variant 4. The resulting isoform (2) is shorter compared to isoform 4.

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8L2PZM8

Related

ENSRNOP00000057042.2, ENSRNOT00000060292.5

Conserved Domains (5) summary

smart00194
Location:530 → 789

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:558 → 789

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:275 → 340

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:5 → 27

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:112 → 166

CD45; Leukocyte receptor CD45
NM_001109890.2 → NP_001103360.1 receptor-type tyrosine-protein phosphatase C isoform 1 precursor

See identical proteins and their annotated locations for NP_001103360.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks three in-frame exons compared to variant 4. The resulting isoform (1) is shorter compared to isoform 4.

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6ICK0, A6ICK1

Conserved Domains (5) summary

smart00194
Location:489 → 748

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:517 → 748

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:234 → 299

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:5 → 27

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:71 → 125

CD45; Leukocyte receptor CD45
NM_001429494.1 → NP_001416423.1 receptor-type tyrosine-protein phosphatase C isoform 6 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013
NM_138507.3 → NP_612516.2 receptor-type tyrosine-protein phosphatase C isoform 4 precursor

See identical proteins and their annotated locations for NP_612516.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P04157

UniProtKB/TrEMBL

A0A8L2QFX7

Related

ENSRNOP00000063859.1, ENSRNOT00000064785.4

Conserved Domains (5) summary

smart00194
Location:621 → 880

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:649 → 880

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:366 → 431

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:5 → 27

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:203 → 257

CD45; Leukocyte receptor CD45

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

52147717..52259810 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090347.1 → XP_038946275.1 receptor-type tyrosine-protein phosphatase C isoform X3

UniProtKB/TrEMBL

A6ICK1

Conserved Domains (5) summary

cd00063
Location:210 → 275

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14557
Location:520 → 720

R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1

cd14558
Location:830 → 1035

R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

pfam12567
Location:47 → 103

CD45; Leukocyte receptor CD45

NF033860
Location:365 → 424

Wzy_O6_O28; oligosaccharide repeat unit polymerase
XM_006249912.4 → XP_006249974.1 receptor-type tyrosine-protein phosphatase C isoform X2

UniProtKB/TrEMBL

A0A8L2QGD4, A6ICK2

Related

ENSRNOP00000030503.5, ENSRNOT00000029878.7

Conserved Domains (6) summary

PHA03255
Location:22 → 149

PHA03255; BDLF3; Provisional

smart00194
Location:579 → 838

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:607 → 838

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:324 → 389

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:5 → 27

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:161 → 215

CD45; Leukocyte receptor CD45
XM_008769534.3 → XP_008767756.1 receptor-type tyrosine-protein phosphatase C isoform X1

UniProtKB/TrEMBL

A6ICK1

Conserved Domains (6) summary

PHA03255
Location:11 → 152

PHA03255; BDLF3; Provisional

smart00194
Location:580 → 839

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:608 → 839

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:325 → 390

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:5 → 27

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:162 → 216

CD45; Leukocyte receptor CD45