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    Glipr1l2 GLI pathogenesis-related 1 like 2 [ Mus musculus (house mouse) ]

    Gene ID: 67537, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Glipr1l2provided by MGI
    Official Full Name
    GLI pathogenesis-related 1 like 2provided by MGI
    Primary source
    MGI:MGI:1914787
    See related
    Ensembl:ENSMUSG00000020214 AllianceGenome:MGI:1914787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921508O11Rik
    Summary
    Predicted to be involved in binding activity of sperm to zona pellucida. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human GLIPR1L2 (GLIPR1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 7.7) See more
    Orthologs
    human all
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    Genomic context

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    See Glipr1l2 in Genome Data Viewer
    Location:
    10 D2; 10 60.09 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111919249..111944003)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (112083344..112108098)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene calcyphosphine 2 pseudogene Neighboring gene GLI pathogenesis-related 1 like 1 Neighboring gene STARR-positive B cell enhancer mm9_chr10:111542860-111543160 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_27896 Neighboring gene GLI pathogenesis-related 1 like 3 Neighboring gene STARR-seq mESC enhancer starr_27897 Neighboring gene calcyphosphine 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels. Kise Y, et al. Biochem Biophys Res Commun, 2006 Dec 8. PMID 17054904
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GLIPR1-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347157.1 → NP_001334086.1  GLIPR1-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC166263, AK014846
      Consensus CDS
      CCDS83755.1
      UniProtKB/Swiss-Prot
      Q9CQ35
      Related
      ENSMUSP00000122771.2, ENSMUST00000148897.8

    2. NM_026223.2 → NP_080499.1  GLIPR1-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_080499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK014846
      Consensus CDS
      CCDS24171.1
      UniProtKB/Swiss-Prot
      Q148R1, Q3TTM5, Q9CQ35
      Related
      ENSMUSP00000020434.4, ENSMUST00000020434.4
      Conserved Domains (1) summary
      cl00133
      Location:49 → 194
      SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      111919249..111944003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513998.1 → XP_006514061.1  GLIPR1-like protein 2 isoform X1

      Conserved Domains (1) summary
      cl00133
      Location:49 → 221
      CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ35.1 GenPept UniProtKB/Swiss-Prot:Q9CQ35

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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