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    ITR1 myo-inositol transporter ITR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852108, updated on 3-Mar-2024

    Summary

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    Gene symbol
    ITR1
    Gene description
    myo-inositol transporter ITR1
    Primary source
    SGD:S000002905
    Locus tag
    YDR497C
    See related
    AllianceGenome:SGD:S000002905
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables myo-inositol transmembrane transporter activity. Involved in myo-inositol transport; pseudohyphal growth; and transmembrane transport. Located in plasma membrane. Orthologous to human SLC2A13 (solute carrier family 2 member 13). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1443713..1445467, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene CORVET complex subunit VPS3 Neighboring gene Puf6p Neighboring gene Sec20p Neighboring gene Lcd1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of the inositol transporter Itr1p by hydrogen peroxide in Saccharomyces cerevisiae. Santos T, et al. Arch Microbiol, 2019 Jan. PMID 30283989
    2. Regulation of inositol transport in Saccharomyces cerevisiae involves inositol-induced changes in permease stability and endocytic degradation in the vacuole. Lai K, et al. J Biol Chem, 1995 Feb 10. PMID 7852314
    3. Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput. Almeida LD, et al. mBio, 2021 Dec 21. PMID 34903049, Free PMC Article
    4. Two major inositol transporters and their role in cryptococcal virulence. Wang Y, et al. Eukaryot Cell, 2011 May. PMID 21398509, Free PMC Article
    5. Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence. Xue C, et al. mBio, 2010 May 18. PMID 20689743, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.
      Title: Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables myo-inositol transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables myo-inositol:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in myo-inositol import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myo-inositol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myo-inositol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyol transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myo-inositol transporter ITR1
    NP_010785.1
    • Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1443713..1445467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180805.1 → NP_010785.1  TPA: myo-inositol transporter ITR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010785.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTB9, P30605
      UniProtKB/TrEMBL
      A0A6A5Q4H8, A6ZZ86, B3LFH0, C7GKT4, G2WBM5, N1P919
      Conserved Domains (1) summary
      cd17360
      Location:92 → 533
      MFS_HMIT_like; H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30605.2

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