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    Rgs8 regulator of G-protein signaling 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54297, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Rgs8provided by RGD
    Official Full Name
    regulator of G-protein signaling 8provided by RGD
    Primary source
    RGD:3571
    See related
    Ensembl:ENSRNOG00000002369 AllianceGenome:RGD:3571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; positive regulation of GTPase activity; and response to amphetamine. Located in dendrite; neuronal cell body membrane; and nucleus. Is extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human RGS8 (regulator of G protein signaling 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 151.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (68355078..68399412)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65804703..65848955)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (71086654..71141820)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene S100 calcium binding protein A11, pseudogene 1 Neighboring gene regulator of G-protein signaling 16 Neighboring gene ribonuclease L

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RGS8 expression in developing cerebellar Purkinje cells. Saitoh O, et al. Biochem Biophys Res Commun, 2003 Oct 3. PMID 13679049
    2. Distribution of regulator of G protein signaling 8 (RGS8) protein in the cerebellum. Saitoh O, et al. Cerebellum, 2003. PMID 12880183
    3. RGS8 protein is distributed in dendrites and cell body of cerebellar Purkinje cell. Itoh M, et al. Biochem Biophys Res Commun, 2001 Sep 14. PMID 11549278
    4. RGS8 accelerates G-protein-mediated modulation of K+ currents. Saitoh O, et al. Nature, 1997 Dec 4. PMID 9394004
    5. Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling. Saitoh O, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12110731, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. examination of expression of mRNA in developing cerebellum by in situ hybridization
      Title: RGS8 expression in developing cerebellar Purkinje cells.
    2. Alternative splicing determines inhibitory function of receptor type-specific Gq signaling.
      Title: Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.
    3. RGS8 protein is distributed in dendrites and cell body but not the nucleus nor axons of cerebellar Purkinje cells, suggesting protein distribution is controlled.
      Title: RGS8 protein is distributed in dendrites and cell body of cerebellar Purkinje cell.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105444

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019344.4 → NP_062217.1  regulator of G-protein signaling 8

      See identical proteins and their annotated locations for NP_062217.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P49804
      UniProtKB/TrEMBL
      A0A8I6AP34, A6ICV3
      Related
      ENSRNOP00000003239.4, ENSRNOT00000003239.7
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      68355078..68399412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250015.5 → XP_006250077.1  regulator of G-protein signaling 8 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6Y1
      Related
      ENSRNOP00000073985.1
      Conserved Domains (1) summary
      cd08711
      Location:98 → 222
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    2. XM_039091040.2 → XP_038946968.1  regulator of G-protein signaling 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AP34

    3. XM_039091035.2 → XP_038946963.1  regulator of G-protein signaling 8 isoform X2

      UniProtKB/Swiss-Prot
      P49804
      UniProtKB/TrEMBL
      A0A8I6AP34, A6ICV3
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    4. XM_039091033.2 → XP_038946961.1  regulator of G-protein signaling 8 isoform X2

      UniProtKB/Swiss-Prot
      P49804
      UniProtKB/TrEMBL
      A0A8I6AP34, A6ICV3
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    5. XM_039091037.2 → XP_038946965.1  regulator of G-protein signaling 8 isoform X2

      UniProtKB/Swiss-Prot
      P49804
      UniProtKB/TrEMBL
      A0A8I6AP34, A6ICV3
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    6. XM_039091042.2 → XP_038946970.1  regulator of G-protein signaling 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AP34
      Related
      ENSRNOP00000090756.1

    7. XM_039091039.2 → XP_038946967.1  regulator of G-protein signaling 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AP34

    8. XM_039091036.2 → XP_038946964.1  regulator of G-protein signaling 8 isoform X2

      UniProtKB/Swiss-Prot
      P49804
      UniProtKB/TrEMBL
      A0A8I6AP34, A6ICV3
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    9. XM_006250016.5 → XP_006250078.1  regulator of G-protein signaling 8 isoform X2

      See identical proteins and their annotated locations for XP_006250078.1

      UniProtKB/Swiss-Prot
      P49804
      UniProtKB/TrEMBL
      A0A8I6AP34, A6ICV3
      Conserved Domains (1) summary
      cd08711
      Location:46 → 170
      RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

    10. XM_039091041.2 → XP_038946969.1  regulator of G-protein signaling 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AP34
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49804.2 GenPept UniProtKB/Swiss-Prot:P49804

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