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    Prl8a2 prolactin family 8, subfamily A, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24315, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Prl8a2provided by RGD
    Official Full Name
    prolactin family 8, subfamily A, member 2provided by RGD
    Primary source
    RGD:2516
    See related
    Ensembl:ENSRNOG00000017048 AllianceGenome:RGD:2516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dprp; Dtprp; Ghd12; d/tPRP
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Involved in female pregnancy. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    17p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (37821651..37830676, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (37613263..37622288, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (39563383..39575777, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene prolactin family 8, subfamily A, member 7 Neighboring gene prolactin family 2, subfamily B, member 1 Neighboring gene prolactin family 6, subfamily A, member 1 Neighboring gene prolactin family 3, subfamily A, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Decidual prolactin-related protein. Identification, molecular cloning, and characterization. Roby KF, et al. J Biol Chem, 1993 Feb 15. PMID 7679108
    2. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, et al. Mamm Genome, 1998 Sep. PMID 9716657
    3. Curated eutherian third party data gene data sets. Premzl M. Data Brief, 2016 Mar. PMID 26862561, Free PMC Article
    4. Third party data gene data set of eutherian growth hormone genes. Premzl M. Genom Data, 2015 Dec. PMID 26697363, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolactin family 8, subfamily A, member 2
    Names
    decidual prolactin-related protein
    decidual/trophoblast prolactin-related protein
    growth hormone d12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418512.1 → NP_001405441.1  prolactin family 8, subfamily A, member 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0M6L0N8, Q4QRA1
      Related
      ENSRNOP00000022923.6, ENSRNOT00000022923.7

    2. NM_022846.3 → NP_074037.1  prolactin family 8, subfamily A, member 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_074037.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I5ZMH5, Q62903, Q63545
      Conserved Domains (1) summary
      cd10288
      Location:29 → 239
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      37821651..37830676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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