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    Prl8a7 prolactin family 8, subfamily A, member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64368, updated on 2-May-2024

    Summary

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    Official Symbol
    Prl8a7provided by RGD
    Official Full Name
    prolactin family 8, subfamily A, member 7provided by RGD
    Primary source
    RGD:620115
    See related
    Ensembl:ENSRNOG00000016933 AllianceGenome:RGD:620115
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ghd10; Prlpd
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    17p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (37767210..37773112)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (37558822..37564724)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (39509516..39515418)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene MLV-related proviral Env polyprotein-like Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 21 Neighboring gene prolactin family 2, subfamily B, member 1 Neighboring gene prolactin family 8, subfamily A, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein D (PLP-D). Iwatsuki K, et al. Endocrinology, 1996 Sep. PMID 8756556
    2. Identification of a novel family of growth hormone-related proteins secreted by rat placenta. Ogilvie S, et al. Endocrinology, 1990 Jun. PMID 2351117
    3. Curated eutherian third party data gene data sets. Premzl M. Data Brief, 2016 Mar. PMID 26862561, Free PMC Article
    4. Third party data gene data set of eutherian growth hormone genes. Premzl M. Genom Data, 2015 Dec. PMID 26697363, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114320

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolactin-8A7
    Names
    PLP-D
    PRL-like protein D
    growth hormone d10
    growth hormone-related protein 1
    placental prolactin-like protein D
    prolactin-like protein D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022537.1 → NP_071982.1  prolactin-8A7 precursor

      See identical proteins and their annotated locations for NP_071982.1

      Status: PROVISIONAL

      Source sequence(s)
      AB000107
      UniProtKB/Swiss-Prot
      P33578, P97786, Q4FZY5
      UniProtKB/TrEMBL
      A6J7S2
      Conserved Domains (1) summary
      cd10288
      Location:30 → 240
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      37767210..37773112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253909.2 → XP_006253971.1  prolactin-8A7 isoform X1

      See identical proteins and their annotated locations for XP_006253971.1

      UniProtKB/TrEMBL
      A0A0G2JTQ7, A0A0M6L0K4, A6J7S2
      Related
      ENSRNOP00000068804.2
      Conserved Domains (1) summary
      cd10288
      Location:31 → 241
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33578.2 GenPept UniProtKB/Swiss-Prot:P33578

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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