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    Zfp180 zinc finger protein 180 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246279, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Zfp180provided by RGD
    Official Full Name
    zinc finger protein 180provided by RGD
    Primary source
    RGD:631380
    See related
    Ensembl:ENSRNOG00000029336 AllianceGenome:RGD:631380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rKr1
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Orthologous to human ZNF180 (zinc finger protein 180). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 151.1), Muscle (RPKM 98.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp180 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88780342..88800637)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79652441..79672737)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80920745..80940038)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily, member 23 Neighboring gene CEA cell adhesion molecule 20 Neighboring gene SUB1 regulator of transcription, pseudogene 1 Neighboring gene thymosin beta-4-like Neighboring gene zinc finger protein 112 Neighboring gene zinc finger protein 235

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A new Cys2/His2 zinc finger gene, rKr1, expressed in oligodendrocytes and neurons. Pott U, et al. Brain Res Mol Brain Res, 1996 May. PMID 8737674
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 180
    Names
    Cys2/His2 zinc finger protein (rKr1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271280.1 → NP_001258209.1  zinc finger protein 180 isoform 2

      See identical proteins and their annotated locations for NP_001258209.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J8W2, A6J8W3, Q62886
      Related
      ENSRNOP00000026077.2, ENSRNOT00000026077.5
      Conserved Domains (4) summary
      COG5048
      Location:292 → 646
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:483 → 503
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:313 → 335
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:523 → 548
      zf-H2C2_2; Zinc-finger double domain

    2. NM_144757.3 → NP_653358.2  zinc finger protein 180 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000001
      Conserved Domains (3) summary
      COG5048
      Location:395 → 657
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:560 → 580
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:685 → 709
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      88780342..88800637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228387.5 → XP_006228449.1  zinc finger protein 180 isoform X1

      See identical proteins and their annotated locations for XP_006228449.1

      UniProtKB/TrEMBL
      A6J8W2, A6J8W3, Q62886
      Related
      ENSRNOP00000082065.1
      Conserved Domains (4) summary
      COG5048
      Location:292 → 646
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:483 → 503
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:313 → 335
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:523 → 548
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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