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    Usp22 ubiquitin specific peptidase 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303201, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Usp22provided by RGD
    Official Full Name
    ubiquitin specific peptidase 22provided by RGD
    Primary source
    RGD:1310354
    See related
    Ensembl:ENSRNOG00000032492 AllianceGenome:RGD:1310354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity and nuclear receptor coactivator activity. Predicted to contribute to H4 histone acetyltransferase activity and thiol-dependent deubiquitinase. Predicted to be involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Predicted to act upstream of or within protein deubiquitination. Predicted to be part of SAGA complex. Orthologous to human USP22 (ubiquitin specific peptidase 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 493.1), Adrenal (RPKM 237.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46328092..46354939, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45828619..45855468, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47429201..47453298, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SRA stem-loop interacting RNA binding protein, pseudogene 1 Neighboring gene TNF receptor superfamily member 13B Neighboring gene small nucleolar RNA SNORA48 Neighboring gene aldehyde dehydrogenase 3 family, member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-specific protease 22 enhances intestinal cell proliferation and tissue regeneration after intestinal ischemia reperfusion injury. Ji AL, et al. World J Gastroenterol, 2019 Feb 21. PMID 30809082, Free PMC Article
    2. Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes. Shi JX, et al. Mol Biosyst, 2016 Apr 26. PMID 26953552
    3. The expression patterns of deubiquitinating enzymes, USP22 and Usp22. Lee HJ, et al. Gene Expr Patterns, 2006 Mar. PMID 16378762
    4. USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A. Zhang XY, et al. Cell Cycle, 2008 Jun 1. PMID 18469533, Free PMC Article
    5. H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology. Belle JI, et al. Int J Biochem Cell Biol, 2014 May. PMID 24647359

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP22 is correlated with promoting intestinal cell proliferation and accelerating intestinal tissue regeneration after intestinal ischemia reperfusion (I/R) injury and may serve as a potential target for therapeutic development for tissue repair during intestinal I/R injury.
      Title: Ubiquitin-specific protease 22 enhances intestinal cell proliferation and tissue regeneration after intestinal ischemia reperfusion injury.
    2. high D-glucose induces increased expression of USP22 in cultured podocytes and diabetic rats. USP22 inhibition confers a protective effect against high glucose-induced podocyte depletion, apoptosis and inflammation.
      Title: Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2A deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2B deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 22
    Names
    ubiquitin specific protease 22
    NP_001178573.1
    XP_063125078.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191644.2 → NP_001178573.1  ubiquitin carboxyl-terminal hydrolase 22

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZTX7
      Related
      ENSRNOP00000044118.4, ENSRNOT00000050061.6
      Conserved Domains (2) summary
      cd02660
      Location:176 → 518
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:63 → 123
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46328092..46354939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269008.1 → XP_063125078.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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