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    GSC2 1,3-beta-glucan synthase GSC2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852920, updated on 13-Apr-2024

    Summary

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    Gene symbol
    GSC2
    Gene description
    1,3-beta-glucan synthase GSC2
    Primary source
    SGD:S000003264
    Locus tag
    YGR032W
    See related
    AllianceGenome:SGD:S000003264
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FKS2
    Summary
    Enables 1,3-beta-D-glucan synthase activity. Involved in (1->3)-beta-D-glucan biosynthetic process and ascospore wall assembly. Located in prospore membrane. Part of 1,3-beta-D-glucan synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (548264..553951)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribonuclease P/MRP protein subunit POP6 Neighboring gene Imo32p Neighboring gene Nag1p Neighboring gene Tim21p Neighboring gene ribosomal 60S subunit protein L26B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Piperazine propanol derivative as a novel antifungal targeting 1,3-beta-D-glucan synthase. Kondoh O, et al. Biol Pharm Bull, 2005 Nov. PMID 16272705
    2. Biosynthesis of the yeast cell wall. II. Regulation of beta-(1 leads to 3)glucan synthetase by ATP and GTP. Shematek EM, et al. J Biol Chem, 1980 Feb 10. PMID 6766140
    3. New Fks hot spot for acquired echinocandin resistance in Saccharomyces cerevisiae and its contribution to intrinsic resistance of Scedosporium species. Johnson ME, et al. Antimicrob Agents Chemother, 2011 Aug. PMID 21576441, Free PMC Article
    4. The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae. Huang LS, et al. Proc Natl Acad Sci U S A, 2005 Aug 30. PMID 16116083, Free PMC Article
    5. Differential sensitivity between Fks1p and Fks2p against a novel beta -1,3-glucan synthase inhibitor, aerothricin3 [corrected]. Kondoh O, et al. J Biol Chem, 2002 Nov 1. PMID 12202487

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ste11 regulates the FKS2 gene through its substrates and through Mpk1.
      Title: Ste11p MEKK signals through HOG, mating, calcineurin and PKC pathways to regulate the FKS2 gene.
    2. The dimeric complex of Mpk1 binds to a Swi4 recognition site in the FKS2 promoter.[Mpk1, Swi4, FKS2]
      Title: Transcriptional reporters for genes activated by cell wall stress through a non-catalytic mechanism involving Mpk1 and SBF.
    3. negative regulation of GSC2 by SMK1 is important for spore wall deposition
      Title: The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1,3-beta-D-glucan synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1,3-beta-D-glucan synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1,3-beta-D-glucan synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in (1->3)-beta-D-glucan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in (1->3)-beta-D-glucan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in (1->3)-beta-D-glucan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in (1->3)-beta-D-glucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore wall assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall polysaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 1,3-beta-D-glucan synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of 1,3-beta-D-glucan synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell periphery HDA PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1,3-beta-glucan synthase GSC2
    NP_011546.3
    • Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      548264..553951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181161.3 → NP_011546.3  TPA: 1,3-beta-glucan synthase GSC2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011546.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUG8, P40989, Q45U52
      UniProtKB/TrEMBL
      A0A8H4C270, G2WEC2, N1P5P7
      Conserved Domains (2) summary
      pfam02364
      Location:827 → 1650
      Glucan_synthase; 1,3-beta-glucan synthase component
      pfam14288
      Location:320 → 428
      FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40989.2

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