GLC3 1,4-alpha-glucan branching enzyme [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: GLC3
Gene description: 1,4-alpha-glucan branching enzyme
Primary source: SGD:S000000737
Locus tag: YEL011W
See related: AllianceGenome:SGD:S000000737
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GHA1
Summary: Enables 1,4-alpha-glucan branching enzyme activity. Involved in glycogen biosynthetic process. Located in cytoplasm. Used to study glycogen storage disease IV. Human ortholog(s) of this gene implicated in glycogen storage disease IV and pulmonary tuberculosis. Orthologous to human GBE1 (1,4-alpha-glucan branching enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 1,4-alpha-glucan branching enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1,4-alpha-glucan branching enzyme activity	IEA Inferred from Electronic Annotation more info
enables 1,4-alpha-glucan branching enzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)	IEA Inferred from Electronic Annotation more info
enables cation binding	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

NP_010905.1

Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease

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The following sections contain reference sequences that belong to a specific genome build. Explain