Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtrprovided by RGD
Official Full Name: 5-methyltetrahydrofolate-homocysteine methyltransferaseprovided by RGD
Primary source: RGD:621283
See related: Ensembl:ENSRNOG00000017593 AllianceGenome:RGD:621283
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: methioninesynthase
Summary: Enables amino acid binding activity; folic acid binding activity; and methionine synthase activity. Involved in several processes, including alpha-amino acid metabolic process; cellular response to methionine; and cellular response to nitric oxide. Predicted to be active in cytosol. Biomarker of type 2 diabetes mellitus and vitamin B12 deficiency. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autistic disorder; hematologic cancer (multiple); hyperhomocysteinemia; and methylmalonic aciduria and homocystinuria type cblG. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 195.0), Adrenal (RPKM 138.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.1

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (62911705..62996544)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (58219998..58308560)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (66210444..66295014, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The objective of this study was to investigate the effects of dietary Zn supply on homocysteine levels and expression of Methionine synthase and betaine-homocysteine methyltransferase in growing rats.
Title: Effects of zinc deficiency and zinc supplementation on homocysteine levels and related enzyme expression in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables cobalamin binding	IEA Inferred from Electronic Annotation more info
enables cobalamin binding	TAS Traceable Author Statement more info	PubMed
enables folic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables methionine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables methionine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables methionine synthase activity	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to methionine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nitric oxide	IDA Inferred from Direct Assay more info	PubMed
involved_in cobalamin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cobalamin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in homocysteine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in homocysteine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in homocysteine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within methionine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in methionine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in methionine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in pteridine-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to axon injury	IDA Inferred from Direct Assay more info	PubMed
involved_in tetrahydrofolate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrofolate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tetrahydrofolate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: methionine synthase

Names: MS; cobalamin-dependent methionine synthase; vitamin-B12 dependent methionine synthase

NP_110491.2

EC 2.1.1.13

XP_038952033.1

EC 2.1.1.13

XP_038952034.1

EC 2.1.1.13

XP_038952035.1

EC 2.1.1.13

XP_038952036.1

EC 2.1.1.13

XP_063132840.1

EC 2.1.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030864.2 → NP_110491.2 methionine synthase

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q9Z2Q4

UniProtKB/TrEMBL

A6KN29, G3V8A4

Related

ENSRNOP00000023973.3, ENSRNOT00000023974.6

Conserved Domains (1) summary

PRK09490
Location:1 → 1249

metH; B12-dependent methionine synthase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

62911705..62996544

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096105.2 → XP_038952033.1 methionine synthase isoform X1

UniProtKB/Swiss-Prot

Q9Z2Q4

UniProtKB/TrEMBL

A6KN29, G3V8A4

Conserved Domains (1) summary

PRK09490
Location:1 → 1249

metH; B12-dependent methionine synthase; Provisional
XM_039096107.2 → XP_038952035.1 methionine synthase isoform X2

UniProtKB/Swiss-Prot

Q9Z2Q4

Conserved Domains (1) summary

PRK09490
Location:1 → 1190

metH; B12-dependent methionine synthase; Provisional
XM_039096108.2 → XP_038952036.1 methionine synthase isoform X4

UniProtKB/TrEMBL

A6KN30

Conserved Domains (1) summary

PRK09490
Location:1 → 853

metH; B12-dependent methionine synthase; Provisional
XM_039096106.2 → XP_038952034.1 methionine synthase isoform X1

UniProtKB/Swiss-Prot

Q9Z2Q4

UniProtKB/TrEMBL

A6KN29, G3V8A4

Conserved Domains (1) summary

PRK09490
Location:1 → 1249

metH; B12-dependent methionine synthase; Provisional
XM_063276770.1 → XP_063132840.1 methionine synthase isoform X3