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    Mtx3 metaxin 3 [ Mus musculus (house mouse) ]

    Gene ID: 382793, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mtx3provided by MGI
    Official Full Name
    metaxin 3provided by MGI
    Primary source
    MGI:MGI:2686040
    See related
    Ensembl:ENSMUSG00000021704 AllianceGenome:MGI:2686040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1194; Gm6514; EG624619; 4930470O13Rik
    Summary
    Predicted to be involved in mitochondrion organization. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Orthologous to human MTX3 (metaxin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 7.2), cerebellum adult (RPKM 6.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 C3; 13 47.78 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (92981251..92994738)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (92844743..92858230)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10807 Neighboring gene STARR-seq mESC enhancer starr_35273 Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene Neighboring gene thrombospondin 4 Neighboring gene STARR-seq mESC enhancer starr_35274 Neighboring gene predicted gene, 31630 Neighboring gene STARR-positive B cell enhancer mm9_chr13:93756683-93756983 Neighboring gene predicted gene, 41019

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. Adolph KW. Gene, 2004 Apr 14. PMID 15087125
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    metaxin-3
    Names
    pleckstrin homology domain containing, family M (with RUN domain) member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162945.2 → NP_001156417.1  metaxin-3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      CT025667
      Consensus CDS
      CCDS49328.1
      UniProtKB/TrEMBL
      D3YTP3
      Related
      ENSMUSP00000075526.4, ENSMUST00000076169.4
      Conserved Domains (2) summary
      cd03212
      Location:105 → 241
      GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
      cd03078
      Location:5 → 77
      GST_N_Metaxin1_like; GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the ...

    RNA

    1. NR_160868.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT025667

    2. NR_160869.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT025667

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      92981251..92994738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517710.2 → XP_006517773.1  metaxin-3 isoform X1

      Conserved Domains (2) summary
      cd03212
      Location:105 → 241
      GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins
      pfam10568
      Location:23 → 142
      Tom37; Outer mitochondrial membrane transport complex protein

    2. XM_006517716.3 → XP_006517779.1  metaxin-3 isoform X2

      See identical proteins and their annotated locations for XP_006517779.1

      Conserved Domains (3) summary
      pfam10568
      Location:23 → 142
      Tom37; Outer mitochondrial membrane transport complex protein
      pfam14650
      Location:14 → 25
      FAM75; FAM75 family
      cl02776
      Location:105 → 196
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    3. XM_006517715.2 → XP_006517778.1  metaxin-3 isoform X2

      See identical proteins and their annotated locations for XP_006517778.1

      Conserved Domains (3) summary
      pfam10568
      Location:23 → 142
      Tom37; Outer mitochondrial membrane transport complex protein
      pfam14650
      Location:14 → 25
      FAM75; FAM75 family
      cl02776
      Location:105 → 196
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    RNA

    1. XR_004938036.1 RNA Sequence

    2. XR_004938038.1 RNA Sequence

    3. XR_004938037.1 RNA Sequence

    4. XR_004938039.1 RNA Sequence

    5. XR_004938040.1 RNA Sequence

    6. XR_004938041.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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