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    Foxn3 forkhead box N3 [ Mus musculus (house mouse) ]

    Gene ID: 71375, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Foxn3provided by MGI
    Official Full Name
    forkhead box N3provided by MGI
    Primary source
    MGI:MGI:1918625
    See related
    Ensembl:ENSMUSG00000033713 AllianceGenome:MGI:1918625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ches1; Ches1l; HTLFL1; 5430426H20Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and protein C-terminus binding activity. Acts upstream of or within craniofacial suture morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; immune system; peripheral nervous system; and sensory organ. Orthologous to human FOXN3 (forkhead box N3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.2), bladder adult (RPKM 8.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 E; 12 49.93 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (99156340..99529926, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (99190081..99563667, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40554 Neighboring gene ribosomal protein L30, pseudogene 8 Neighboring gene STARR-positive B cell enhancer mm9_chr12:100322425-100322726 Neighboring gene STARR-seq mESC enhancer starr_33006 Neighboring gene RIKEN cDNA 4930474N09 gene Neighboring gene centromere protein W pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:100567328-100567481 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:100567519-100567702 Neighboring gene RIKEN cDNA 3300002A11 gene Neighboring gene VISTA enhancer mm12 Neighboring gene predicted gene, 46371 Neighboring gene STARR-positive B cell enhancer ABC_E1861 Neighboring gene STARR-seq mESC enhancer starr_33022 Neighboring gene STARR-positive B cell enhancer ABC_E7165 Neighboring gene STARR-seq mESC enhancer starr_33023 Neighboring gene STARR-seq mESC enhancer starr_33024 Neighboring gene predicted gene, 51999 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:100797804-100797957 Neighboring gene STARR-positive B cell enhancer mm9_chr12:100801158-100801458 Neighboring gene predicted gene, 26839 Neighboring gene predicted gene, 53755 Neighboring gene predicted gene, 35644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of retinal amacrine cell generation by miR-216b and Foxn3. Zhang H, et al. Development, 2022 Jan 15. PMID 34919141, Free PMC Article
    2. A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose. Karanth S, et al. Cell Rep, 2018 Jul 10. PMID 29996093, Free PMC Article
    3. MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer. Li Q, et al. PLoS One, 2012. PMID 23133627, Free PMC Article
    4. Characterization of mouse and human nude genes. Schorpp M, et al. Immunogenetics, 1997. PMID 9321431
    5. Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects. Samaan G, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20691664

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of retinal amacrine cell generation by miR-216b and Foxn3.
      Title: Regulation of retinal amacrine cell generation by miR-216b and Foxn3.
    2. liver FOXN3 and glucagon control fasting glucose.
      Title: A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose.
    3. MIRN574 microRNA, mouse/*METAB
      Title: MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer.
    4. the Foxn3 mutation leads to partial embryonic and postnatal lethality, growth retardation, eye formation defects, dental anomalies and craniofacial defects.
      Title: Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transposon induced (2) 
    • Gene trapped (1) 
    • Endonuclease-mediated (5)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36260, MGC107530

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within craniofacial suture morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein N3
    Names
    checkpoint suppressor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183186.2 → NP_899009.2  forkhead box protein N3

      See identical proteins and their annotated locations for NP_899009.2

      Status: VALIDATED

      Source sequence(s)
      AI448353, AK046748, BE623611, BY717160
      Consensus CDS
      CCDS26103.1
      UniProtKB/Swiss-Prot
      Q499D0, Q8C5N8, Q9CU83
      Related
      ENSMUSP00000082189.2, ENSMUST00000085108.8
      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      99156340..99529926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516239.4 → XP_006516302.1  forkhead box protein N3 isoform X3

      See identical proteins and their annotated locations for XP_006516302.1

      UniProtKB/Swiss-Prot
      Q499D0, Q8C5N8, Q9CU83
      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    2. XM_006516232.5 → XP_006516295.1  forkhead box protein N3 isoform X1

      See identical proteins and their annotated locations for XP_006516295.1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    3. XM_030246927.2 → XP_030102787.1  forkhead box protein N3 isoform X2

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    4. XM_036157616.1 → XP_036013509.1  forkhead box protein N3 isoform X3

      UniProtKB/Swiss-Prot
      Q499D0, Q8C5N8, Q9CU83
      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    5. XM_036157615.1 → XP_036013508.1  forkhead box protein N3 isoform X2

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    6. XM_030246925.2 → XP_030102785.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    7. XM_030246929.2 → XP_030102789.1  forkhead box protein N3 isoform X3

      UniProtKB/Swiss-Prot
      Q499D0, Q8C5N8, Q9CU83
      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    8. XM_030246928.1 → XP_030102788.1  forkhead box protein N3 isoform X2

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    9. XM_006516233.3 → XP_006516296.1  forkhead box protein N3 isoform X1

      See identical proteins and their annotated locations for XP_006516296.1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    10. XM_036157617.1 → XP_036013510.1  forkhead box protein N3 isoform X3

      UniProtKB/Swiss-Prot
      Q499D0, Q8C5N8, Q9CU83
      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    11. XM_030246926.1 → XP_030102786.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    12. XM_006516236.5 → XP_006516299.1  forkhead box protein N3 isoform X1

      See identical proteins and their annotated locations for XP_006516299.1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    13. XM_006516240.3 → XP_006516303.1  forkhead box protein N3 isoform X3

      See identical proteins and their annotated locations for XP_006516303.1

      UniProtKB/Swiss-Prot
      Q499D0, Q8C5N8, Q9CU83
      Related
      ENSMUSP00000135082.2, ENSMUST00000177451.8
      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    14. XM_006516234.3 → XP_006516297.1  forkhead box protein N3 isoform X1

      See identical proteins and their annotated locations for XP_006516297.1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    15. XM_017315205.2 → XP_017170694.1  forkhead box protein N3 isoform X2

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)

    16. XM_036157614.1 → XP_036013507.1  forkhead box protein N3 isoform X1

      Conserved Domains (1) summary
      cd20059
      Location:114 → 203
      FH_FOXN3; Forkhead (FH) domain found in Forkhead box protein N3 (FOXN3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499D0.1 GenPept UniProtKB/Swiss-Prot:Q499D0

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