Dpp10 dipeptidylpeptidase 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpp10provided by MGI
Official Full Name: dipeptidylpeptidase 10provided by MGI
Primary source: MGI:MGI:2442409
See related: Ensembl:ENSMUSG00000036815 AllianceGenome:MGI:2442409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DPP X; Dprp3; 6430601K09Rik
Summary: Enables potassium channel regulator activity. Involved in protein localization to plasma membrane and regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex marginal layer; and cortical subplate. Human ortholog(s) of this gene implicated in asthma. Orthologous to human DPP10 (dipeptidyl peptidase like 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 14.7), cortex adult (RPKM 13.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 53.68 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (123259871..124773774, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (123332138..124845815, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results show that a Dpp10 point mutation leads to increased airway responsiveness following allergen challenge.
Title: Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma.
In the presence of DPP6 or DPP10, cell surface Kv4.2 protein expression is selectively increased.
Title: Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit442 (e-PCR), detects polymorphism
- UniSTS:128811

D1Mit239 (e-PCR), detects polymorphism
- UniSTS:128582

RH144555 (e-PCR)
- UniSTS:233800

BB238853 (e-PCR)
- UniSTS:207201

D1Mit311 (e-PCR), detects polymorphism
- UniSTS:128669

D1Mit519 (e-PCR), detects polymorphism
- UniSTS:142254

D1Mit341 (e-PCR), detects polymorphism
- UniSTS:128699

D1Mit392 (e-PCR), detects polymorphism
- UniSTS:128753

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables dipeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inactive dipeptidyl peptidase 10

Names: dipeptidyl peptidase X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.