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    CG12766 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38462, updated on 11-Apr-2024

    Summary

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    Official Symbol
    CG12766provided by FlyBase
    Primary source
    FLYBASE:FBgn0035476
    Locus tag
    Dmel_CG12766
    See related
    AllianceGenome:FB:FBgn0035476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12766
    Summary
    Predicted to enable alditol:NADP+ 1-oxidoreductase activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal 8; diabetic neuropathy; diabetic retinopathy; leukemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B); AKR1B10 (aldo-keto reductase family 1 member B10); and AKR1B15 (aldo-keto reductase family 1 member B15). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    64A1-64A1; 3-10 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3938624..3940125, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3938624..3940125, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ecdysone-induced protein 63F 1 Neighboring gene antisense RNA:Ecdysone-induced gene 63F 2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43916 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms. Sujkowski A, et al. Aging (Albany NY), 2015 Aug. PMID 26298685, Free PMC Article
    2. Defensive repertoire of Drosophila larvae in response to toxic fungi. Trienens M, et al. Mol Ecol, 2017 Oct. PMID 28746736
    3. Innate immune responses to paraquat exposure in a Drosophila model of Parkinson's disease. Maitra U, et al. Sci Rep, 2019 Sep 3. PMID 31481676, Free PMC Article
    4. First transcriptome profiling of D. melanogaster after development in a deep underground low radiation background laboratory. Zarubin M, et al. PLoS One, 2021. PMID 34351964, Free PMC Article
    5. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12766-PA
    NP_647839.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3938624..3940125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139582.3 → NP_647839.1  uncharacterized protein Dmel_CG12766 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647839.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZK8
      Related
      FBpp0073029
      Conserved Domains (2) summary
      COG0656
      Location:5 → 298
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:12 → 299
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZK8 Q9VZK8

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