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    DET3 vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837840, updated on 7-Sep-2023

    Summary

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    Gene symbol
    DET3
    Gene description
    vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3)
    Primary source
    Araport:AT1G12840
    Locus tag
    AT1G12840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA VACUOLAR ATP SYNTHASE SUBUNIT C; ATVHA-C; DE-ETIOLATED 3; F13K23.9; F13K23_9; VACUOLAR ATP SYNTHASE SUBUNIT C
    Summary
    Encodes subunit C of the vacuolar H(+)-ATPase (V-ATPase). Bound and phosphorylated by AtWNK8.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (4374205..4378514)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene proline-rich family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene auxin signaling F-box 3 Neighboring gene nucleolin Neighboring gene uncharacterized protein Neighboring gene Phosphoglycerate mutase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis det3 mutant reveals a central role for the vacuolar H(+)-ATPase in plant growth and development. Schumacher K, et al. Genes Dev, 1999 Dec 15. PMID 10617574, Free PMC Article
    2. A WNK kinase binds and phosphorylates V-ATPase subunit C. Hong-Hermesdorf A, et al. FEBS Lett, 2006 Feb 6. PMID 16427632
    3. Comparison of lignin deposition in three ectopic lignification mutants. Rogers LA, et al. New Phytol, 2005 Oct. PMID 16159327
    4. SOS2 promotes salt tolerance in part by interacting with the vacuolar H+-ATPase and upregulating its transport activity. Batelli G, et al. Mol Cell Biol, 2007 Nov. PMID 17875927, Free PMC Article
    5. Arabidopsis TRANSCURVATA1 encodes NUP58, a component of the nucleopore central channel. Ferrández-Ayela A, et al. PLoS One, 2013. PMID 23840761, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_101154.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to proton-transporting ATPase activity, rotational mechanism IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lignin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of carbohydrate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane HDA PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3)
    NP_563916.1
    • DE-ETIOLATED 3 (DET3); FUNCTIONS IN: proton-transporting ATPase activity, rotational mechanism; INVOLVED IN: lignin biosynthetic process, regulation of carbohydrate biosynthetic process, unidimensional cell growth; LOCATED IN: in 6 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, V1 complex, subunit C (InterPro:IPR004907); Has 563 Blast hits to 541 proteins in 227 species: Archae - 0; Bacteria - 0; Metazoa - 263; Fungi - 140; Plants - 72; Viruses - 0; Other Eukaryotes - 88 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4374205..4378514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101154.4 → NP_563916.1  vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SDS7
      UniProtKB/TrEMBL
      A0A178WM16, A0A384KX64, C0SUV0
      Conserved Domains (2) summary
      cd14785
      Location:57 → 77
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:6 → 368
      V-ATPase_C; V-ATPase subunit C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SDS7.1

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