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    Tasl TLR adaptor interacting with endolysosomal SLC15A4 [ Mus musculus (house mouse) ]

    Gene ID: 71398, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Taslprovided by MGI
    Official Full Name
    TLR adaptor interacting with endolysosomal SLC15A4provided by MGI
    Primary source
    MGI:MGI:1918648
    See related
    Ensembl:ENSMUSG00000025058 AllianceGenome:MGI:1918648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5430427O19Rik
    Summary
    Predicted to be involved in positive regulation of innate immune response; positive regulation of toll-like receptor signaling pathway; and regulation of lysosomal lumen pH. Predicted to act upstream of or within innate immune response. Predicted to be located in endolysosome membrane. Orthologous to human TASL (TLR adaptor interacting with endolysosomal SLC15A4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Tasl in Genome Data Viewer
    Location:
    X C1; X 39.39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (84820445..84935105)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (85776968..85891499)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene TGF-beta activated kinase 1/MAP3K7 binding protein 3 Neighboring gene predicted gene, 39523 Neighboring gene STARR-seq mESC enhancer starr_47495 Neighboring gene STARR-seq mESC enhancer starr_47496 Neighboring gene glycerol kinase Neighboring gene STARR-positive B cell enhancer ABC_E8762 Neighboring gene replication protein A 14 kDa subunit pseudogene Neighboring gene mitochondrial import receptor subunit TOM20 homolog pseudogene Neighboring gene predicted gene 14762 Neighboring gene predicted gene, 54063 Neighboring gene STARR-seq mESC enhancer starr_47497 Neighboring gene spermatogenesis associated multipass transmembrane protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of toll-like receptor 7 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of toll-like receptor 8 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lysosomal lumen pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lysosomal lumen pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endolysosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TLR adapter interacting with SLC15A4 on the lysosome
    Names
    protein CXorf21 homolog
    uncharacterized protein CXorf21 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163539.1 → NP_001157011.1  TLR adapter interacting with SLC15A4 on the lysosome

      See identical proteins and their annotated locations for NP_001157011.1

      Status: VALIDATED

      Source sequence(s)
      AK017351, AK155591, AL672066, BY203970
      Consensus CDS
      CCDS53127.1
      UniProtKB/Swiss-Prot
      Q9D3J9
      UniProtKB/TrEMBL
      Q08EG0
      Related
      ENSMUSP00000109609.2, ENSMUST00000113976.2
      Conserved Domains (1) summary
      pfam15133
      Location:1 → 293
      DUF4569; Domain of unknown function (DUF4569)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      84820445..84935105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247682.3 → XP_011245984.1  TLR adapter interacting with SLC15A4 on the lysosome isoform X1

      See identical proteins and their annotated locations for XP_011245984.1

      UniProtKB/Swiss-Prot
      Q9D3J9
      UniProtKB/TrEMBL
      Q08EG0
      Conserved Domains (1) summary
      pfam15133
      Location:1 → 293
      DUF4569; Domain of unknown function (DUF4569)

    2. XM_017318620.3 → XP_017174109.1  TLR adapter interacting with SLC15A4 on the lysosome isoform X1

      UniProtKB/Swiss-Prot
      Q9D3J9
      UniProtKB/TrEMBL
      Q08EG0
      Conserved Domains (1) summary
      pfam15133
      Location:1 → 293
      DUF4569; Domain of unknown function (DUF4569)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3J9.1 GenPept UniProtKB/Swiss-Prot:Q9D3J9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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