Fut1 fucosyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fut1provided by RGD
Official Full Name: fucosyltransferase 1provided by RGD
Primary source: RGD:2638
See related: Ensembl:ENSRNOG00000020995 AllianceGenome:RGD:2638
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Futa
Summary: Predicted to enable galactoside 2-alpha-L-fucosyltransferase activity. Predicted to be involved in several processes, including positive regulation of endothelial cell migration; positive regulation of endothelial cell-matrix adhesion via fibronectin; and positive regulation of sprouting angiogenesis. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Orthologous to human FUT1 (fucosyltransferase 1 (H blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 10.1), Lung (RPKM 8.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (105223399..105226817)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (96086934..96090352)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (101599018..101602440)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-(1,2)-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables alpha-(1,2)-fucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables galactoside 2-alpha-L-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside 2-alpha-L-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fucosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fucosylation	ISO Inferred from Sequence Orthology more info
involved_in fucosylation	ISO Inferred from Sequence Orthology more info
involved_in fucosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in olfactory bulb development	ISO Inferred from Sequence Orthology more info
involved_in olfactory bulb development	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galactoside alpha-(1,2)-fucosyltransferase 1

Names: GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; alpha 1,2-fucosyltransferase A; alpha 12-fucosyltransferase; alpha(1,2)FT 1; alpha12-fucosyltransferase a; fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase); galactoside 2-alpha-L-fucosyltransferase 1; type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1; type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1

NP_112515.1

EC 2.4.1.344

EC 2.4.1.69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.