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    CG18858 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326109, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG18858provided by FlyBase
    Primary source
    FLYBASE:FBgn0042175
    Locus tag
    Dmel_CG18858
    See related
    AllianceGenome:FB:FBgn0042175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38C.53; Dmel\CG18858
    Summary
    Enables serine hydrolase activity. Predicted to be involved in lipid metabolic process. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to several human genes including PLA2G15 (phospholipase A2 group XV). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    38C7-38C7; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20456847..20459075, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20456847..20459075, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43607 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44980 Neighboring gene Cell division cycle 23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel regulators of planar cell polarity: a genetic analysis in Drosophila. Weber U, et al. Genetics, 2012 May. PMID 22391484, Free PMC Article
    2. Map position and expression of the genes in the 38 region of Drosophila. Butler H, et al. Genetics, 2001 Aug. PMID 11514449, Free PMC Article
    3. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    4. GlycoFly: a database of Drosophila N-linked glycoproteins identified using SPEG--MS techniques. Baycin-Hizal D, et al. J Proteome Res, 2011 Jun 3. PMID 21480662
    5. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18858-PA
    CG18858-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20456847..20459075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273699.1 → NP_001260628.1  uncharacterized protein Dmel_CG18858, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260628.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGK6, Q9I7L9
      Conserved Domains (1) summary
      cl21494
      Location:81 → 405
      Abhydrolase; alpha/beta hydrolases

    2. NM_144443.2 → NP_652700.1  uncharacterized protein Dmel_CG18858, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652700.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGK6, Q9I7L9
      Related
      FBpp0080896
      Conserved Domains (1) summary
      cl21494
      Location:81 → 405
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7L9 Q9I7L9

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