Hpca hippocalcin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hpcaprovided by MGI
Official Full Name: hippocalcinprovided by MGI
Primary source: MGI:MGI:1336200
See related: Ensembl:ENSMUSG00000028785 AllianceGenome:MGI:1336200
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including actin binding activity; calcium ion binding activity; and identical protein binding activity. Acts upstream of or within inner ear development. Predicted to be located in several cellular components, including dendrite; neuronal cell body membrane; and perikaryon. Predicted to be extrinsic component of membrane. Is expressed in ganglia and telencephalon. Human ortholog(s) of this gene implicated in torsion dystonia 2. Orthologous to human HPCA (hippocalcin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 184.5), frontal lobe adult (RPKM 103.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 62.88 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (129005363..129019712, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (129111570..129125919, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hippocalcin hasa protective role in heatstroke-induced hypothalamic injury in mice.
Title: Proteomic identification of hippocalcin and its protective role in heatstroke-induced hypothalamic injury in mice.
neurogenic markers, including doublecortin and the neuronal nuclei antigen, and hippocalcin, otub1, and spectrin-alpha are potential molecular links between hippocampal neurogenesis and exercise in the elderly.
Title: Moderate-Intensity Exercise Induces Neurogenesis and Improves Cognition in Old Mice by Upregulating Hippocampal Hippocalcin, Otub1, and Spectrin-α.
results suggest that 7,8-Dihydroxy-4-methylcoumarin prevents glutamate-induced toxicity by scavenging free radicals and regulating hippocalcin expression.
Title: 7,8-Dihydroxy-4-methylcoumarin provides neuroprotection by increasing hippocalcin expression.
Hippocalcin and KCNQ channels contribute to the kinetics of the slow afterhyperpolarization
Title: Hippocalcin and KCNQ channels contribute to the kinetics of the slow afterhyperpolarization.
Suggest that the maintenance of parvalbumin and hippocalcin levels by melatonin in ischemic injury contributes to the neuroprotective effect of melatonin against neuronal cell damage.
Title: Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury.
An age-dependent increase in neurodegeneration occurred in the gene-deleted mice, showing that hippocalcin contributes to neuronal viability during aging.
Title: Hippocalcin protects against caspase-12-induced and age-dependent neuronal degeneration.
These results suggest that hippocalcin plays a crucial role in the Ca(2+)-signaling pathway that underlies long-lasting neural plasticity and that leads to spatial and associative memory.
Title: Hippocalcin-deficient mice display a defect in cAMP response element-binding protein activation associated with impaired spatial and associative memory.
These results suggest that hippocalcin plays an important role in calcium extrusion from neurons and, in turn, helps to protect them against calcium-dependent excitotoxin damage in the hippocampus.
Title: Hippocalcin protects hippocampal neurons against excitotoxin damage by enhancing calcium extrusion.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AB015200 (e-PCR)
- UniSTS:163348

D5Wox35 (e-PCR)
- UniSTS:239939

AI507302 (e-PCR)
- UniSTS:164258

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to L-glutamate	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in dendritic spine head	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuron-specific calcium-binding protein hippocalcin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130419.3 → NP_001123891.1 neuron-specific calcium-binding protein hippocalcin isoform 1

See identical proteins and their annotated locations for NP_001123891.1

Status: VALIDATED

Source sequence(s)

AL606977

Consensus CDS

CCDS18682.1

UniProtKB/Swiss-Prot

A2A7R4, P84075

UniProtKB/TrEMBL

E9PV73

Related

ENSMUSP00000129548.2, ENSMUST00000164649.8

Conserved Domains (1) summary

COG5126
Location:13 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001286081.2 → NP_001273010.1 neuron-specific calcium-binding protein hippocalcin isoform 1

See identical proteins and their annotated locations for NP_001273010.1

Status: VALIDATED

Source sequence(s)

AL606977

Consensus CDS

CCDS18682.1

UniProtKB/Swiss-Prot

A2A7R4, P84075

UniProtKB/TrEMBL

E9PV73

Related

ENSMUSP00000119178.3, ENSMUST00000139450.8

Conserved Domains (1) summary

COG5126
Location:13 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001286083.2 → NP_001273012.1 neuron-specific calcium-binding protein hippocalcin isoform 1

See identical proteins and their annotated locations for NP_001273012.1

Status: VALIDATED

Source sequence(s)

AL606977

Consensus CDS

CCDS18682.1

UniProtKB/Swiss-Prot

A2A7R4, P84075

UniProtKB/TrEMBL

E9PV73

Related

ENSMUSP00000112143.3, ENSMUST00000116442.9

Conserved Domains (1) summary

COG5126
Location:13 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001421088.1 → NP_001408017.1 neuron-specific calcium-binding protein hippocalcin isoform 1

Status: VALIDATED

Source sequence(s)

AL606977

UniProtKB/Swiss-Prot

A2A7R4, P84075
NM_001421089.1 → NP_001408018.1 neuron-specific calcium-binding protein hippocalcin isoform 1

Status: VALIDATED

Source sequence(s)

AL606977

UniProtKB/Swiss-Prot

A2A7R4, P84075
NM_001421090.1 → NP_001408019.1 neuron-specific calcium-binding protein hippocalcin isoform 1

Status: VALIDATED

Source sequence(s)

AL606977

UniProtKB/Swiss-Prot

A2A7R4, P84075
NM_001421091.1 → NP_001408020.1 neuron-specific calcium-binding protein hippocalcin isoform 2

Status: VALIDATED

Source sequence(s)

AL606977
NM_001421092.1 → NP_001408021.1 neuron-specific calcium-binding protein hippocalcin isoform 1

Status: VALIDATED

Source sequence(s)

AL606977

UniProtKB/Swiss-Prot

A2A7R4, P84075
NM_010471.5 → NP_034601.1 neuron-specific calcium-binding protein hippocalcin isoform 1

See identical proteins and their annotated locations for NP_034601.1

Status: VALIDATED

Source sequence(s)

AL606977

Consensus CDS

CCDS18682.1

UniProtKB/Swiss-Prot

A2A7R4, P84075

UniProtKB/TrEMBL

E9PV73

Related

ENSMUSP00000030572.4, ENSMUST00000030572.10

Conserved Domains (1) summary

COG5126
Location:13 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RNA

NR_185239.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL606977
NR_185240.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL606977
NR_185241.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL606977

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

129005363..129019712 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253224.1 → XP_030109084.1 neuron-specific calcium-binding protein hippocalcin isoform X1

UniProtKB/Swiss-Prot

A2A7R4, P84075

UniProtKB/TrEMBL

E9PV73

Conserved Domains (1) summary

COG5126
Location:13 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_006502775.4 → XP_006502838.1 neuron-specific calcium-binding protein hippocalcin isoform X1

See identical proteins and their annotated locations for XP_006502838.1

UniProtKB/Swiss-Prot

A2A7R4, P84075

UniProtKB/TrEMBL

E9PV73

Related

ENSMUSP00000112145.3, ENSMUST00000116444.10

Conserved Domains (1) summary

COG5126
Location:13 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_030253225.1 → XP_030109085.1 neuron-specific calcium-binding protein hippocalcin isoform X1

UniProtKB/Swiss-Prot

A2A7R4, P84075

UniProtKB/TrEMBL

E9PV73

Conserved Domains (1) summary

COG5126
Location:13 → 179

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]