Wdr5 WD repeat domain 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr5provided by MGI
Official Full Name: WD repeat domain 5provided by MGI
Primary source: MGI:MGI:2155884
See related: Ensembl:ENSMUSG00000026917 AllianceGenome:MGI:2155884
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Big; Big-3; 2410008O07Rik
Summary: Predicted to enable methylated histone binding activity. Predicted to contribute to histone methyltransferase activity (H3-K4 specific). Acts upstream of or within histone H3-K4 methylation; positive regulation of gluconeogenesis; and skeletal system development. Located in nucleus. Part of ATAC complex. Is expressed in cerebral cortex; testis; and vault of skull. Orthologous to human WDR5 (WD repeat domain 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 20.0), limb E14.5 (RPKM 18.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.38 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (27405159..27426547)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (27515147..27536535)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Wdr5 attenuates MLL-rearranged leukemogenesis by suppressing Myc targets.
Title: Loss of Wdr5 attenuates MLL-rearranged leukemogenesis by suppressing Myc targets.
p53 inactivation unmasks histone methylation-independent WDR5 functions that drive self-renewal and differentiation of pluripotent stem cells.
Title: p53 inactivation unmasks histone methylation-independent WDR5 functions that drive self-renewal and differentiation of pluripotent stem cells.
Our results show that an enrichment of activating histone marks at the Runx2/p57 P1 promoter is accompanied by the simultaneous interaction of Wdr5 and Utx proteins in differentiating MC3T3 mouse osteoblasts
Title: Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts.
Cbx8 associates with non-PRC1 complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch gene expression.
Title: Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis.
Wdr5 suppression also reduced IFNgamma, Il-1beta, and TNFalpha induced chemokine gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis
Title: The TrxG Complex Mediates Cytokine Induced De Novo Enhancer Formation in Islets.
results suggest that specific RNAs are integral inputs into the WDR5-MLL complex for maintenance of the active chromatin state and embryonic stem cell fates
Title: Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency.
Data show that broad association of myc proto-oncogene protein MYC with chromatin depends on interaction with the WD40-repeat protein WDR5.
Title: Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.
BIG3 inhibits insulin granule biogenesis and insulin secretion.
Title: BIG3 inhibits insulin granule biogenesis and insulin secretion.
BIG3 negatively regulates insulin granule exocytosis by restricting insulin granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected.
Title: Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3-knockout mice.
Depletion of KAT2B or WDR5 decreased gluconeogenic gene expression.
Title: Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124766 (e-PCR)
- UniSTS:161588

RH126890 (e-PCR)
- UniSTS:209759

AA960360 (e-PCR)
- UniSTS:158934

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H3K4 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of gluconeogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-lysine methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of gluconeogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1/2 complex	ISO Inferred from Sequence Orthology more info
part_of MLL3/4 complex	ISO Inferred from Sequence Orthology more info
part_of NSL complex	ISO Inferred from Sequence Orthology more info
part_of Set1C/COMPASS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set1C/COMPASS complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: WD repeat-containing protein 5

Names: BMP2-induced 3-kb gene protein; WD repeat-containing protein BIG-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080848.2 → NP_543124.1 WD repeat-containing protein 5

See identical proteins and their annotated locations for NP_543124.1

Status: VALIDATED

Source sequence(s)

AA023626, AF416510

Consensus CDS

CCDS15829.1

UniProtKB/Swiss-Prot

P61965, Q922C9

UniProtKB/TrEMBL

Q3UNQ3

Related

ENSMUSP00000109585.4, ENSMUST00000113952.10

Conserved Domains (2) summary

cd00200
Location:37 → 331

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:48 → 85

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

27405159..27426547

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497672.4 → XP_006497735.1 WD repeat-containing protein 5 isoform X1

See identical proteins and their annotated locations for XP_006497735.1

UniProtKB/Swiss-Prot

P61965, Q922C9

UniProtKB/TrEMBL

Q3UNQ3

Conserved Domains (2) summary

cd00200
Location:37 → 331

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:48 → 85

7WD40; WD40 repeat [structural motif]