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    Acy1 aminoacylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 109652, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Acy1provided by MGI
    Official Full Name
    aminoacylase 1provided by MGI
    Primary source
    MGI:MGI:87913
    See related
    Ensembl:ENSMUSG00000023262 AllianceGenome:MGI:87913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acy-1; 1110014J22Rik
    Summary
    Predicted to enable aminoacylase activity and identical protein binding activity. Predicted to be involved in cellular amino acid metabolic process. Predicted to be located in extracellular exosome. Orthologous to human ACY1 (aminoacylase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in duodenum adult (RPKM 66.0), kidney adult (RPKM 51.7) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acy1 in Genome Data Viewer
    Location:
    9 F1; 9 57.49 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106310180..106315594, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106432981..106438236, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33616 Neighboring gene predicted gene, 46131 Neighboring gene STARR-seq mESC enhancer starr_25150 Neighboring gene ribosomal protein L29 Neighboring gene STARR-positive B cell enhancer ABC_E11423 Neighboring gene abhydrolase domain containing 14A Neighboring gene abhydrolase domain containing 14b Neighboring gene poly(rC) binding protein 4 Neighboring gene G protein-coupled receptor 62

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metabolite profiling of CKD progression in the chronic renal insufficiency cohort study. Wen D, et al. JCI Insight, 2022 Oct 24. PMID 36048534, Free PMC Article
    2. Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure. Lai Q, et al. Acta Pharmacol Sin, 2022 Aug. PMID 34916608, Free PMC Article
    3. Aminoacylase 1 is a sphingosine kinase 1-interacting protein. Maceyka M, et al. FEBS Lett, 2004 Jun 18. PMID 15196915
    4. Bioautographic visualization of aminoacylase-1: assignment of the structural gene ACY-1 to chromosome 3 in man. Naylor SL, et al. Somatic Cell Genet, 1979 Jan. PMID 373141
    5. A chromosomal segment conserved since divergence of lineages leading to man and mouse: the gene order of aminoacylase-1, transferrin, and beta-galactosidase on mouse chromosome 9. Nadeau JH. Genet Res, 1986 Dec. PMID 3106151

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure.
      Title: Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminoacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aminoacylase-1
    Names
    N-acyl-L-amino-acid amidohydrolase
    NP_001263371.1
    NP_079647.1
    XP_036010451.1
    XP_036010452.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276442.1 → NP_001263371.1  aminoacylase-1

      See identical proteins and their annotated locations for NP_001263371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK003703, BX529990, CV560337
      Consensus CDS
      CCDS23477.1
      UniProtKB/Swiss-Prot
      Q99JW2, Q9CR15
      UniProtKB/TrEMBL
      A0A0R4J050
      Related
      ENSMUST00000190851.3
      Conserved Domains (2) summary
      cd05646
      Location:9 → 399
      M20_AcylaseI_like; M20 Aminoacylase-I like subfamily
      TIGR01880
      Location:1 → 401
      Ac-peptdase-euk; N-acyl-L-amino-acid amidohydrolase

    2. NM_025371.3 → NP_079647.1  aminoacylase-1

      See identical proteins and their annotated locations for NP_079647.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK003703, BX529990
      Consensus CDS
      CCDS23477.1
      UniProtKB/Swiss-Prot
      Q99JW2, Q9CR15
      UniProtKB/TrEMBL
      A0A0R4J050
      Related
      ENSMUSP00000024031.7, ENSMUST00000024031.13
      Conserved Domains (2) summary
      cd05646
      Location:9 → 399
      M20_AcylaseI_like; M20 Aminoacylase-I like subfamily
      TIGR01880
      Location:1 → 401
      Ac-peptdase-euk; N-acyl-L-amino-acid amidohydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106310180..106315594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154558.1 → XP_036010451.1  aminoacylase-1 isoform X1

      UniProtKB/TrEMBL
      A0A1L1SS90
      Conserved Domains (1) summary
      cl14876
      Location:2 → 312
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. XM_036154559.1 → XP_036010452.1  aminoacylase-1 isoform X1

      UniProtKB/TrEMBL
      A0A1L1SS90
      Conserved Domains (1) summary
      cl14876
      Location:2 → 312
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JW2.1 GenPept UniProtKB/Swiss-Prot:Q99JW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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