Drc3 dynein regulatory complex subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Drc3provided by MGI
Official Full Name: dynein regulatory complex subunit 3provided by MGI
Primary source: MGI:MGI:1921915
See related: Ensembl:ENSMUSG00000056598 AllianceGenome:MGI:1921915
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: m6Bei; Lrrc48; 4930449E07Rik
Summary: Predicted to be located in axoneme. Is expressed in brain; inner ear; lung epithelium; nasal cavity epithelium; and spinal cord ventricular layer. Orthologous to human DRC3 (dynein regulatory complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 20.8), ovary adult (RPKM 4.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.81 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (60243063..60285168)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (60352881..60394342)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice.
Title: DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice.
Mutations in Lrrc48 cause hydrocephalus, laterality defects, and sinusitis.
Title: Mutations in Dnaaf1 and Lrrc48 Cause Hydrocephalus, Laterality Defects, and Sinusitis in Mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dynein regulatory complex subunit 3

Names: leucine rich repeat containing 48; leucine-rich repeat-containing protein 48; novel Leucine Rich Repeat domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029044.2 → NP_083320.1 dynein regulatory complex subunit 3

See identical proteins and their annotated locations for NP_083320.1

Status: PROVISIONAL

Source sequence(s)

AK015430

Consensus CDS

CCDS36172.1

UniProtKB/Swiss-Prot

Q9D5E4

UniProtKB/TrEMBL

F6Q537

Related

ENSMUSP00000104363.3, ENSMUST00000108723.9

Conserved Domains (2) summary

sd00031
Location:67 → 88

LRR_1; leucine-rich repeat [structural motif]

cd21340
Location:53 → 200

PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

60243063..60285168

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157053.1 → XP_036012946.1 dynein regulatory complex subunit 3 isoform X1

UniProtKB/Swiss-Prot

Q9D5E4

UniProtKB/TrEMBL

F6Q537

Conserved Domains (2) summary

sd00031
Location:67 → 88

LRR_1; leucine-rich repeat [structural motif]

cd21340
Location:53 → 200

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_006534382.5 → XP_006534445.1 dynein regulatory complex subunit 3 isoform X2

Conserved Domains (1) summary

pfam14580
Location:7 → 56

LRR_9; Leucine-rich repeat