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    Zzz3 zinc finger, ZZ domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 108946, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zzz3provided by MGI
    Official Full Name
    zinc finger, ZZ domain containing 3provided by MGI
    Primary source
    MGI:MGI:1920453
    See related
    Ensembl:ENSMUSG00000039068 AllianceGenome:MGI:1920453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110065C23Rik; 6430567E01Rik
    Summary
    Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in histone H4 acetylation. Part of ATAC complex. Is expressed in ureter. Orthologous to human ZZZ3 (zinc finger ZZ-type containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.9), CNS E18 (RPKM 7.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 H3; 3 77.16 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152101110..152168463)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152395473..152462826)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm72 Neighboring gene mitoguardin 1 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene predicted gene, 57837 Neighboring gene RIKEN cDNA 3110067G11 gene Neighboring gene STARR-positive B cell enhancer ABC_E4606 Neighboring gene adenylate kinase 5 Neighboring gene expressed sequence AI115009

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
    2. The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes. Nagy Z, et al. Cell Mol Life Sci, 2010 Feb. PMID 19936620
    3. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ZZ-type zinc finger-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080755.2 → NP_001074224.1  ZZ-type zinc finger-containing protein 3 isoform a

      See identical proteins and their annotated locations for NP_001074224.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC111139, AC122529
      Consensus CDS
      CCDS38674.1
      UniProtKB/Swiss-Prot
      Q3TMK6, Q3V189, Q6KAQ7
      Related
      ENSMUSP00000101706.3, ENSMUST00000106100.9
      Conserved Domains (3) summary
      cd02341
      Location:828 → 878
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:662 → 710
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    2. NM_001287139.1 → NP_001274068.1  ZZ-type zinc finger-containing protein 3 isoform b

      See identical proteins and their annotated locations for NP_001274068.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.
      Source sequence(s)
      AC111139, BC060614, BY305239
      Consensus CDS
      CCDS71338.1
      UniProtKB/TrEMBL
      D3YTT9
      Related
      ENSMUSP00000087428.5, ENSMUST00000089982.11
      Conserved Domains (3) summary
      cd02341
      Location:827 → 877
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:661 → 709
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    3. NM_001346655.1 → NP_001333584.1  ZZ-type zinc finger-containing protein 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC111139, AK165882
      Consensus CDS
      CCDS84698.1
      UniProtKB/Swiss-Prot
      Q6KAQ7
      Related
      ENSMUSP00000101709.2, ENSMUST00000106103.8
      Conserved Domains (2) summary
      cd02341
      Location:327 → 377
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:161 → 209
      Myb_DNA-binding; Myb-like DNA-binding domain

    4. NM_001355673.1 → NP_001342602.1  ZZ-type zinc finger-containing protein 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC122529
      Consensus CDS
      CCDS38674.1
      UniProtKB/Swiss-Prot
      Q3TMK6, Q3V189, Q6KAQ7
      Conserved Domains (3) summary
      cd02341
      Location:828 → 878
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:662 → 710
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      152101110..152168463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319423.3 → XP_017174912.1  ZZ-type zinc finger-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q3TMK6, Q3V189, Q6KAQ7
      Conserved Domains (3) summary
      cd02341
      Location:828 → 878
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:662 → 710
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    2. XM_006500852.5 → XP_006500915.1  ZZ-type zinc finger-containing protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006500915.1

      UniProtKB/TrEMBL
      D3YTT9
      Conserved Domains (3) summary
      cd02341
      Location:827 → 877
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:661 → 709
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    3. XM_011239984.4 → XP_011238286.1  ZZ-type zinc finger-containing protein 3 isoform X3

      Conserved Domains (1) summary
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    4. XM_006500854.5 → XP_006500917.1  ZZ-type zinc finger-containing protein 3 isoform X5

      Conserved Domains (1) summary
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    5. XM_006500853.5 → XP_006500916.1  ZZ-type zinc finger-containing protein 3 isoform X4

      Conserved Domains (1) summary
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    6. XM_006500857.5 → XP_006500920.1  ZZ-type zinc finger-containing protein 3 isoform X8

      See identical proteins and their annotated locations for XP_006500920.1

      UniProtKB/Swiss-Prot
      Q6KAQ7
      Conserved Domains (2) summary
      cd02341
      Location:327 → 377
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:161 → 209
      Myb_DNA-binding; Myb-like DNA-binding domain

    7. XM_006500855.5 → XP_006500918.1  ZZ-type zinc finger-containing protein 3 isoform X6

      Conserved Domains (2) summary
      cd02341
      Location:332 → 382
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:166 → 214
      Myb_DNA-binding; Myb-like DNA-binding domain

    8. XM_036162811.1 → XP_036018704.1  ZZ-type zinc finger-containing protein 3 isoform X4

      Conserved Domains (1) summary
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    9. XM_006500856.5 → XP_006500919.1  ZZ-type zinc finger-containing protein 3 isoform X7

      See identical proteins and their annotated locations for XP_006500919.1

      UniProtKB/Swiss-Prot
      Q6KAQ7
      Related
      ENSMUSP00000143693.2, ENSMUST00000200570.5
      Conserved Domains (2) summary
      cd02341
      Location:331 → 381
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:165 → 213
      Myb_DNA-binding; Myb-like DNA-binding domain

    10. XM_030252353.2 → XP_030108213.1  ZZ-type zinc finger-containing protein 3 isoform X8

      Conserved Domains (2) summary
      cd02341
      Location:327 → 377
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:161 → 209
      Myb_DNA-binding; Myb-like DNA-binding domain

    11. XM_006500848.5 → XP_006500911.1  ZZ-type zinc finger-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006500911.1

      UniProtKB/Swiss-Prot
      Q3TMK6, Q3V189, Q6KAQ7
      Related
      ENSMUSP00000101707.2, ENSMUST00000106101.2
      Conserved Domains (3) summary
      cd02341
      Location:828 → 878
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:662 → 710
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    12. XM_030252350.2 → XP_030108210.1  ZZ-type zinc finger-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q3TMK6, Q3V189, Q6KAQ7
      Conserved Domains (3) summary
      cd02341
      Location:828 → 878
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:662 → 710
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    13. XM_030252352.2 → XP_030108212.1  ZZ-type zinc finger-containing protein 3 isoform X6

      Conserved Domains (2) summary
      cd02341
      Location:332 → 382
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:166 → 214
      Myb_DNA-binding; Myb-like DNA-binding domain

    14. XM_006500850.4 → XP_006500913.1  ZZ-type zinc finger-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006500913.1

      UniProtKB/Swiss-Prot
      Q3TMK6, Q3V189, Q6KAQ7
      Conserved Domains (3) summary
      cd02341
      Location:828 → 878
      ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam00249
      Location:662 → 710
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam14757
      Location:343 → 418
      NSP2-B_epitope; Immunogenic region of nsp2 protein of arterivirus polyprotein

    RNA

    1. XR_867209.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198416.2: Suppressed sequence

      Description
      NM_198416.2: This RefSeq was permanently suppressed because currently there is support for the protein but not for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6KAQ7.2 GenPept UniProtKB/Swiss-Prot:Q6KAQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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