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    Arhgef16 Rho guanine nucleotide exchange factor 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687105, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Arhgef16provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 16provided by RGD
    Primary source
    RGD:1588981
    See related
    Ensembl:ENSRNOG00000046803 AllianceGenome:RGD:1588981
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity; cell chemotaxis; and positive regulation of protein localization to plasma membrane. Orthologous to human ARHGEF16 (Rho guanine nucleotide exchange factor 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 46.1), Lung (RPKM 20.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (170126573..170148624, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (164843656..164866212, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (171626450..171649124, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene tumor protein p63 regulated 1-like Neighboring gene multiple EGF-like-domains 6 Neighboring gene PR/SET domain 16 Neighboring gene uncharacterized LOC102555433 Neighboring gene uncharacterized LOC120103049

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. Oliver AW, et al. Br J Cancer, 2011 Jan 18. PMID 21139582, Free PMC Article
    2. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. Hiramoto-Yamaki N, et al. J Cell Biol, 2010 Aug 9. PMID 20679435, Free PMC Article
    3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187446

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 16
    Names
    Rho guanine nucleotide exchange factor (GEF) 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127591.1 → NP_001121063.1  rho guanine nucleotide exchange factor 16

      See identical proteins and their annotated locations for NP_001121063.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166429
      UniProtKB/TrEMBL
      A0A0G2K2L6, B2GUW2
      Related
      ENSRNOP00000066478.1, ENSRNOT00000072786.3
      Conserved Domains (3) summary
      cd11938
      Location:633 → 684
      SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
      cd01221
      Location:489 → 622
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:288 → 466
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      170126573..170148624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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