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    Mvb12a multivesicular body subunit 12A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290635, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Mvb12aprovided by RGD
    Official Full Name
    multivesicular body subunit 12Aprovided by RGD
    Primary source
    RGD:735220
    See related
    Ensembl:ENSRNOG00000017949 AllianceGenome:RGD:735220
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam125a
    Summary
    Predicted to enable lipid binding activity and ubiquitin binding activity. Predicted to be involved in several processes, including endosome to lysosome transport via multivesicular body sorting pathway; receptor catabolic process; and virus maturation. Predicted to be located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Predicted to be part of ESCRT I complex. Predicted to be active in cytosol. Orthologous to human MVB12A (multivesicular body subunit 12A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 140.1), Lung (RPKM 122.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18286231..18291096)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18252227..18257111)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19973611..19978479)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 39 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase like 1 Neighboring gene transmembrane protein 221 Neighboring gene nucleoredoxin-like 1 Neighboring gene solute carrier family 27 member 1 Neighboring gene 6-phosphogluconolactonase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I MVB12 subunit. Boura E, et al. Proc Natl Acad Sci U S A, 2012 Feb 7. PMID 22232651, Free PMC Article
    2. Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications. Tsunematsu T, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20654576
    3. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Morita E, et al. Cell Host Microbe, 2007 Jul 12. PMID 18005716, Free PMC Article
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72581

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in viral budding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in viral budding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in virus maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in virus maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ESCRT I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    multivesicular body subunit 12A
    Names
    ESCRT-I complex subunit MVB12A
    family with sequence similarity 125, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199375.1 → NP_955407.1  multivesicular body subunit 12A

      See identical proteins and their annotated locations for NP_955407.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061799
      UniProtKB/Swiss-Prot
      Q6P777
      UniProtKB/TrEMBL
      A0A8L2UJY5, A6K9V5
      Related
      ENSRNOP00000024413.4, ENSRNOT00000024413.7
      Conserved Domains (1) summary
      pfam10240
      Location:8 → 259
      DUF2464; Multivesicular body subunit 12

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18286231..18291096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275153.1 → XP_063131223.1  multivesicular body subunit 12A isoform X4

    2. XM_006252860.5 → XP_006252922.1  multivesicular body subunit 12A isoform X1

      UniProtKB/TrEMBL
      A6K9V7
      Conserved Domains (1) summary
      pfam10240
      Location:8 → 212
      DUF2464; Protein of unknown function (DUF2464)

    3. XM_063275151.1 → XP_063131221.1  multivesicular body subunit 12A isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIU5

    4. XM_063275152.1 → XP_063131222.1  multivesicular body subunit 12A isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P777.1 GenPept UniProtKB/Swiss-Prot:Q6P777

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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