Lrp1 LDL receptor related protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrp1provided by RGD
Official Full Name: LDL receptor related protein 1provided by RGD
Primary source: RGD:1307535
See related: Ensembl:ENSRNOG00000025053 AllianceGenome:RGD:1307535
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LRP-1
Summary: Enables coreceptor activity and protease binding activity. Involved in several processes, including positive regulation of transport; regulation of cytosolic calcium ion concentration; and regulation of neuron projection development. Located in several cellular components, including axonal growth cone; cytoplasmic vesicle; and neuronal cell body. Used to study diabetes mellitus. Biomarker of Alzheimer's disease; prostate carcinoma in situ; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 783.5), Adrenal (RPKM 435.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 90

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65265639..65346196, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63380325..63461029, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (70846313..70927028, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Red-light radiation: does it enhance memory by increasing hippocampal LRP-1 and TRPA-1 genes expression?
Title: Red-light radiation: does it enhance memory by increasing hippocampal LRP-1 and TRPA-1 genes expression?
The protective role of hippocampal LRP1 knockdown involves synaptic plasticity through the promoting microtubule dynamics and activation of Akt/GSK-3beta pathway in depressive rats.
Title: The protective role of hippocampal LRP1 knockdown involves synaptic plasticity through the promoting microtubule dynamics and activation of Akt/GSK-3β pathway in depressive rats.
The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer's disease.
Title: The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer's disease.
A soluble derivative of PrP(C) activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor.
Title: A soluble derivative of PrP(C) activates cell-signaling and regulates cell physiology through LRP1 and the NMDA receptor.
Low density lipoprotein receptor-related protein 1 regulates cardiac hypertrophy induced by pressure overload.
Title: Low density lipoprotein receptor-related protein 1 regulates cardiac hypertrophy induced by pressure overload.
Study shows there is interaction between ApoE4 gene and aluminum on the Abeta content, especially the change of the Abeta42 content, which may be related to the down-regulation of the expression of ApoER2 and LRP1 proteins.
Title: Effect of Aluminum-Maltolate on the Content of Aβ Protein and the Expression of ApoER2, VLDLRs, and LRP1 in PC12-ApoE4 Cells.
we demonstrated that LRP1 activation by apoE-mimic peptide COG1410 attenuated WMI and improved neurological function by modulating microglial polarization toward M2 phenotypes after SAH. This regulation was at least in part through Shc1/PI3K/Akt signaling.
Title: LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats.
These results suggest that LF promoted lipolysis in mature adipocytes by regulating the expression levels of proteins involved in lipolysis through controlling the activity of cAMP/ERK signaling pathways via LRP1
Title: Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes.
Data suggest both LRP1 and LRP2 are necessary in growth cones for ligand- (zinc metallothionein IIa-)mediated chemotactic calcium-dependent signal transduction in sensory neurons, for axon guidance/neurogenesis, and for peripheral nerve regeneration.
Title: Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration.
Data show that LDL-receptor related protein 1 (LRP1)-mediated cardiomyocyte intracellular cholesteryl ester accumulation alters the structural and physical characteristics of secreted tropoelastin through an increase in cathepsin S mature protein levels.
Title: Cardiomyocyte intracellular cholesteryl ester accumulation promotes tropoelastin physical alteration and degradation: Role of LRP1 and cathepsin S.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225342

RH132158 (e-PCR)
- UniSTS:215441

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-2 macroglobulin receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha-2 macroglobulin receptor activity	ISO Inferred from Sequence Orthology more info
enables apolipoprotein binding	IBA Inferred from Biological aspect of Ancestor more info
enables apolipoprotein binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables cargo receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables clathrin heavy chain binding	IEA Inferred from Electronic Annotation more info
enables clathrin heavy chain binding	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta clearance by cellular catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance by cellular catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance by cellular catabolic process	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta clearance by transcytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance by transcytosis	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance by transcytosis	ISO Inferred from Sequence Orthology more info
involved_in aorta morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in astrocyte activation involved in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac septum development	ISO Inferred from Sequence Orthology more info
involved_in cellular lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemoattraction of axon	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in enzyme-linked receptor protein signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lysosomal transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Schwann cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in regeneration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collateral sprouting of injured axon	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lysosomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of pulmonary blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	NAS Non-traceable Author Statement more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in insulin-responsive compartment	IDA Inferred from Direct Assay more info	PubMed
part_of low-density lipoprotein receptor complex	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prolow-density lipoprotein receptor-related protein 1

Names: low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130490.1 → NP_001123962.1 prolow-density lipoprotein receptor-related protein 1 precursor

See identical proteins and their annotated locations for NP_001123962.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/Swiss-Prot

G3V928, Q5I0H1

Related

ENSRNOP00000034210.4, ENSRNOT00000031005.6

Conserved Domains (9) summary

smart00192
Location:3494 → 3527

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:3095 → 3137

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:2983 → 3012

EGF_CA; Calcium-binding EGF-like domain

COG3386
Location:2254 → 2464

YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]

cd00112
Location:3576 → 3610

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:4014 → 4054

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam12662
Location:2963 → 2986

cEGF; Complement Clr-like EGF-like

pfam14670
Location:808 → 843

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:72 → 109

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

65265639..65346196 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765393.3 → XP_008763615.1 prolow-density lipoprotein receptor-related protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A0U0

Related

ENSRNOP00000085719.1

Conserved Domains (8) summary

smart00192
Location:3511 → 3544

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:3112 → 3154

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:3000 → 3029

EGF_CA; Calcium-binding EGF-like domain

COG3386
Location:2271 → 2481

YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]

cd00112
Location:3593 → 3627

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:4031 → 4071

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam12662
Location:2980 → 3003

cEGF; Complement Clr-like EGF-like

pfam14670
Location:808 → 843

FXa_inhibition; Coagulation Factor Xa inhibitory site