Noc2 Nucleolar complex protein 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Noc2provided by FlyBase
Official Full Name: Nucleolar complex protein 2provided by FlyBase
Primary source: FLYBASE:FBgn0032925
Locus tag: Dmel_CG9246
See related: AllianceGenome:FB:FBgn0032925
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9246; Dmel\CG9246; NOC2?
Summary: Predicted to enable histone binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of histone acetylation; negative regulation of transcription by RNA polymerase II; and ribosomal large subunit biogenesis. Predicted to be part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Predicted to be active in nucleolus and nucleoplasm. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval muscle system; extended germ band embryo; and gut section. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (21163641..21166090)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (21163641..21166090)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Noc1p-Noc2p complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Noc1p-Noc2p complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of Noc2p-Noc3p complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Noc2p-Noc3p complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info