Ttyh1 tweety family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ttyh1provided by RGD
Official Full Name: tweety family member 1provided by RGD
Primary source: RGD:1310103
See related: Ensembl:ENSRNOG00000032699 AllianceGenome:RGD:1310103
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity; intracellular calcium activated chloride channel activity; and volume-sensitive chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within several processes, including cell-cell adhesion; cell-substrate adhesion; and filopodium assembly. Predicted to be located in filopodium membrane; filopodium tip; and synapse. Predicted to be part of chloride channel complex. Predicted to be active in plasma membrane and smooth endoplasmic reticulum membrane. Orthologous to human TTYH1 (tweety family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 682.2) and Testes (RPKM 132.2) See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (79125564..79144137, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (70053312..70071872, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (73734614..73753157, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest a role for Ttyh1 in process formation, cell adhesion and possibly as a transmembrane receptor.
Title: Expression and evolution of the mammalian brain gene Ttyh1.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Ttyh1 (e-PCR), detects polymorphism
- UniSTS:507293

RH128306 (e-PCR)
- UniSTS:211614

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
NOT enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly calcium-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables volume-sensitive anion channel activity	ISO Inferred from Sequence Orthology more info
enables volume-sensitive chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables volume-sensitive chloride channel activity	ISO Inferred from Sequence Orthology more info
enables volume-sensitive chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within filopodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in filopodium tip	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in smooth endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in smooth endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: protein tweety homolog 1

Names: tweety homolog 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.