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    Testin testin gene [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286916, updated on 29-Feb-2024

    Summary

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    Official Symbol
    Testinprovided by RGD
    Official Full Name
    testin geneprovided by RGD
    Primary source
    RGD:708447
    See related
    Ensembl:ENSRNOG00000018028 AllianceGenome:RGD:708447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Located in cell junction. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 172.6), Adrenal (RPKM 12.1) and 1 other tissue See more
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    Genomic context

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    Location:
    17p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (3829012..3864995)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (3824222..3859385)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (4194796..4225376)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene trophoblast specific protein alpha Neighboring gene cytotoxic T lymphocyte-associated protein 2 alpha Neighboring gene thioredoxin-related transmembrane protein 3, pseudogene 1 Neighboring gene cathepsin L-like 3 Neighboring gene cathepsin 7 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Testins are structurally related to the mouse cysteine proteinase precursor but devoid of any protease/anti-protease activity. Cheng CY, et al. Biochem Biophys Res Commun, 1993 Feb 26. PMID 8447824
    2. Rat testin is a newly identified component of the junctional complexes in various tissues whose mRNA is predominantly expressed in the testis and ovary. Grima J, et al. Biol Reprod, 1995 Feb. PMID 7711203
    3. Testins are structurally related Sertoli cell proteins whose secretion is tightly coupled to the presence of germ cells. Cheng CY, et al. J Biol Chem, 1989 Dec 15. PMID 2592382
    4. Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization. Su L, et al. J Cell Physiol, 2020 Sep. PMID 31975378
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization.
      Title: Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testin-2
    Names
    CMB-23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173132.2 → NP_775155.1  testin-2 precursor

      See identical proteins and their annotated locations for NP_775155.1

      Status: PROVISIONAL

      Source sequence(s)
      U16858
      UniProtKB/Swiss-Prot
      P15242, P15243
      UniProtKB/TrEMBL
      A6KAF2
      Related
      ENSRNOP00000024467.1, ENSRNOT00000024467.3
      Conserved Domains (2) summary
      smart00848
      Location:29 → 87
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:114 → 332
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      3829012..3864995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095434.2 → XP_038951362.1  testin-2 isoform X1

      UniProtKB/Swiss-Prot
      P15242, P15243
      UniProtKB/TrEMBL
      A6KAF2
      Conserved Domains (2) summary
      smart00848
      Location:29 → 87
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:114 → 332
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15242.2 GenPept UniProtKB/Swiss-Prot:P15242

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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