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    Cpxm2 carboxypeptidase X (M14 family), member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293566, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cpxm2provided by RGD
    Official Full Name
    carboxypeptidase X (M14 family), member 2provided by RGD
    Primary source
    RGD:1310955
    See related
    Ensembl:ENSRNOG00000015902 AllianceGenome:RGD:1310955
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310955
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be active in extracellular space. Orthologous to human CPXM2 (carboxypeptidase X, M14 family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 131.6), Thymus (RPKM 63.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cpxm2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (196266930..196377350, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (186836797..186947222, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204048785..204161090, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485183 Neighboring gene G protein-coupled receptor 26 Neighboring gene ribosomal protein S27, pseudogene 7 Neighboring gene uncharacterized LOC102551752 Neighboring gene carbohydrate sulfotransferase 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Grabowski K, et al. Hypertens Res, 2022 Feb. PMID 34916661, Free PMC Article
    2. Identification of mouse CPX-2, a novel member of the metallocarboxypeptidase gene family: cDNA cloning, mRNA distribution, and protein expression and characterization. Xin X, et al. DNA Cell Biol, 1998 Oct. PMID 9809751
    3. Proteomics characterization of extracellular space components in the human aorta. Didangelos A, et al. Mol Cell Proteomics, 2010 Sep. PMID 20551380, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
      Title: Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive carboxypeptidase-like protein X2
    Names
    carboxypeptidase X 2 (M14 family)
    carboxypeptidase X2
    metallocarboxypeptidase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106306.1 → NP_001099776.1  inactive carboxypeptidase-like protein X2 precursor

      See identical proteins and their annotated locations for NP_001099776.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6HWX9, D4A536
      Related
      ENSRNOP00000042501.6, ENSRNOT00000051853.6
      Conserved Domains (4) summary
      cd03869
      Location:320 → 645
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
      cd11308
      Location:649 → 724
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      smart00231
      Location:144 → 299
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:143 → 298
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      196266930..196377350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107648.2 → XP_038963576.1  inactive carboxypeptidase-like protein X2 isoform X1

      Conserved Domains (2) summary
      cd00057
      Location:143 → 298
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd03869
      Location:324 → 645
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

    2. XM_039107652.2 → XP_038963580.1  inactive carboxypeptidase-like protein X2 isoform X2

      Conserved Domains (3) summary
      cd11308
      Location:416 → 491
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cd00057
      Location:1 → 65
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd03869
      Location:91 → 412
      M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

    3. XM_063286426.1 → XP_063142496.1  inactive carboxypeptidase-like protein X2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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