Phb2 prohibitin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Phb2provided by RGD
Official Full Name: prohibitin 2provided by RGD
Primary source: RGD:620203
See related: Ensembl:ENSRNOG00000012999 AllianceGenome:RGD:620203
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bap; Bap37; Bap-37; Bcap27; Bcap37
Summary: Predicted to enable several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including cellular response to hypoxia; cellular response to retinoic acid; and negative regulation of apoptotic process. Located in mitochondrion and nucleus. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Colocalizes with axon. Orthologous to human PHB2 (prohibitin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 934.7), Adrenal (RPKM 835.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (159203948..159208561)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (157517662..157522268)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (157230769..157235375)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oxidative stress suppresses PHB2-mediated mitophagy in beta-cells via the Nrf2/PHB2 pathway.
Title: Oxidative stress suppresses PHB2-mediated mitophagy in β-cells via the Nrf2/PHB2 pathway.
PHB2 Alleviates Neurotoxicity of Prion Peptide PrP[106-126] via PINK1/Parkin-Dependent Mitophagy.
Title: PHB2 Alleviates Neurotoxicity of Prion Peptide PrP(106-126) via PINK1/Parkin-Dependent Mitophagy.
Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia.
Title: Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia.
COMP-prohibitin 2 interaction in mitochondria plays an important role in maintaining the contractile phenotype of Vascular smooth muscle cells by regulating mitochondrial oxidative phosphorylation.
Title: COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity.
PHB2 participated in the pathological process response to sciatic nerve injury.
Title: Dynamic change of Prohibitin2 expression in rat sciatic nerve after crush.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_4161-4162:996679469:1 (e-PCR)
- UniSTS:269337

RH128209 (e-PCR)
- UniSTS:211517

RH142323 (e-PCR)
- UniSTS:231570

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amide binding	IEA Inferred from Electronic Annotation more info
enables amide binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sphingolipid binding	IEA Inferred from Electronic Annotation more info
enables sphingolipid binding	ISO Inferred from Sequence Orthology more info
enables sphingolipid binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in B cell activation	IEA Inferred from Electronic Annotation more info
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in B cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in CD40 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in CD40 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in RIG-I signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in mammary gland alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
involved_in mammary gland branching involved in thelarche	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland branching involved in thelarche	ISO Inferred from Sequence Orthology more info
involved_in mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell cycle G1/S phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exit from mitosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of branching involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiolipin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiolipin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiolipin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in sister chromatid cohesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of inner mitochondrial membrane protein complex	ISO Inferred from Sequence Orthology more info
part_of inner mitochondrial membrane protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial prohibitin complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial prohibitin complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial prohibitin complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prohibitin-2

Names: B-cell receptor associated protein 37; B-cell receptor-associated protein BAP37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013035.1 → NP_001013053.1 prohibitin-2

See identical proteins and their annotated locations for NP_001013053.1

Status: PROVISIONAL

Source sequence(s)

BC083705

UniProtKB/Swiss-Prot

P70629, P70630, Q5XIH7

UniProtKB/TrEMBL

A0A0G2KB63

Related

ENSRNOP00000075668.2, ENSRNOT00000091464.2

Conserved Domains (2) summary

smart00244
Location:39 → 201

PHB; prohibitin homologues

cd03401
Location:40 → 235

SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily