P4ha3 prolyl 4-hydroxylase subunit alpha 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P4ha3provided by RGD
Official Full Name: prolyl 4-hydroxylase subunit alpha 3provided by RGD
Primary source: RGD:735150
See related: Ensembl:ENSRNOG00000017118 AllianceGenome:RGD:735150
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables procollagen-proline 4-dioxygenase activity. Predicted to be involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in endoplasmic reticulum lumen. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 48.6), Thymus (RPKM 34.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (164040852..164075922)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (154628723..154663779)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (165295835..165330922)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of collagen prolyl 4-hydroxylase isoenzyme 3, its expression and catalytic properties
Title: Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 4-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables procollagen-proline 4-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 4-dioxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
part_of procollagen-proline 4-dioxygenase complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: prolyl 4-hydroxylase subunit alpha-3

Names: 4-PH alpha-3; collagen prolyl 4-hydroxylase alpha III subunit; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3; prolyl 4-hydroxylase, alpha polypeptide III

NP_942070.1

EC 1.14.11.2

XP_038938408.1

EC 1.14.11.2

XP_063123235.1

EC 1.14.11.2

XP_063123241.1

EC 1.14.11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198775.1 → NP_942070.1 prolyl 4-hydroxylase subunit alpha-3 precursor

See identical proteins and their annotated locations for NP_942070.1

Status: PROVISIONAL

Source sequence(s)

AY313450

UniProtKB/Swiss-Prot

Q6W3E9

UniProtKB/TrEMBL

F1LQ79

Related

ENSRNOP00000049901.2, ENSRNOT00000046943.3

Conserved Domains (2) summary

smart00702
Location:356 → 528

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

pfam08336
Location:33 → 159

P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

164040852..164075922

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267171.1 → XP_063123241.1 prolyl 4-hydroxylase subunit alpha-3 isoform X3
XM_039082480.2 → XP_038938408.1 prolyl 4-hydroxylase subunit alpha-3 isoform X1

UniProtKB/TrEMBL

F1LQ79

Conserved Domains (2) summary

smart00702
Location:356 → 478

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

pfam08336
Location:34 → 108

P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
XM_063267165.1 → XP_063123235.1 prolyl 4-hydroxylase subunit alpha-3 isoform X2