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    Foxn2 forkhead box N2 [ Mus musculus (house mouse) ]

    Gene ID: 14236, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Foxn2provided by MGI
    Official Full Name
    forkhead box N2provided by MGI
    Primary source
    MGI:MGI:1347478
    See related
    Ensembl:ENSMUSG00000034998 AllianceGenome:MGI:1347478
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HTLF; Fkh19; Foxn1; 3230402J05Rik; 6030465J18Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; limb bud; and nervous system. Orthologous to human FOXN2 (forkhead box N2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.0), cerebellum adult (RPKM 3.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Foxn2 in Genome Data Viewer
    Location:
    17 E4; 17 57.97 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88746430..88797961)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (88440704..88490533)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31615 Neighboring gene STARR-seq mESC enhancer starr_43551 Neighboring gene predicted gene, 22542 Neighboring gene STARR-seq mESC enhancer starr_43553 Neighboring gene predicted gene, 23947 Neighboring gene STARR-positive B cell enhancer ABC_E5644 Neighboring gene STARR-seq mESC enhancer starr_43555 Neighboring gene STARR-seq mESC enhancer starr_43556 Neighboring gene predicted gene, 57646 Neighboring gene STARR-seq mESC enhancer starr_43557 Neighboring gene STARR-seq mESC enhancer starr_43559 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88929251-88929552 Neighboring gene protein phosphatase 1, regulatory subunit 21 Neighboring gene STARR-positive B cell enhancer mm9_chr17:88980789-88981089 Neighboring gene stonin 1 Neighboring gene predicted gene, 31704

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of mouse and human nude genes. Schorpp M, et al. Immunogenetics, 1997. PMID 9321431
    2. The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis. Tribioli C, et al. Mech Dev, 2002 Oct. PMID 12351180
    3. Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Wu J, et al. Proc Natl Acad Sci U S A, 2014 Jul 15. PMID 24982181, Free PMC Article
    4. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Rajan S, et al. Physiol Genomics, 2012 Feb 1. PMID 22147266
    5. Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Machold R, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21440680, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The dynamic and specific expression of Foxn2 during embryonic development suggest multiple independent roles for Foxn2 function during gestation
      Title: The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box protein N2
    Names
    forkhead box N1
    forkhead homolog 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355742.1 → NP_001342671.1  forkhead box protein N2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165091, AW495021
      Consensus CDS
      CCDS29022.2
      UniProtKB/TrEMBL
      E9Q7L6
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    2. NM_001355743.1 → NP_001342672.1  forkhead box protein N2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165091, AW495021
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    3. NM_180974.5 → NP_851305.2  forkhead box protein N2 isoform 1

      See identical proteins and their annotated locations for NP_851305.2

      Status: VALIDATED

      Source sequence(s)
      AK086861, AK162076, AW495021, BB042729, BU152350, CB524750, CJ145725, CJ173433, CN698353, CO431378
      Consensus CDS
      CCDS29022.2
      UniProtKB/TrEMBL
      E9Q7L6
      Related
      ENSMUSP00000107857.3, ENSMUST00000112238.9
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      88746430..88797961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160317.1 → XP_036016210.1  forkhead box protein N2 isoform X1

      UniProtKB/TrEMBL
      E9Q7L6
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    2. XM_036160319.1 → XP_036016212.1  forkhead box protein N2 isoform X2

      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    3. XM_036160320.1 → XP_036016213.1  forkhead box protein N2 isoform X3

      UniProtKB/TrEMBL
      O08673, Q8BSS2
      Conserved Domains (1) summary
      cl00061
      Location:111 → 192
      FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins

    4. XM_036160318.1 → XP_036016211.1  forkhead box protein N2 isoform X2

      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    5. XM_006523653.5 → XP_006523716.1  forkhead box protein N2 isoform X1

      See identical proteins and their annotated locations for XP_006523716.1

      UniProtKB/TrEMBL
      E9Q7L6
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    6. XM_036160316.1 → XP_036016209.1  forkhead box protein N2 isoform X1

      UniProtKB/TrEMBL
      E9Q7L6
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    7. XM_030249498.2 → XP_030105358.1  forkhead box protein N2 isoform X2

      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    8. XM_006523654.4 → XP_006523717.1  forkhead box protein N2 isoform X1

      See identical proteins and their annotated locations for XP_006523717.1

      UniProtKB/TrEMBL
      E9Q7L6
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    9. XM_006523652.3 → XP_006523715.1  forkhead box protein N2 isoform X1

      See identical proteins and their annotated locations for XP_006523715.1

      UniProtKB/TrEMBL
      E9Q7L6
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    10. XM_030249497.2 → XP_030105357.1  forkhead box protein N2 isoform X1

      UniProtKB/TrEMBL
      E9Q7L6
      Conserved Domains (1) summary
      cd20058
      Location:111 → 192
      FH_FOXN2; Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2)

    RNA

    1. XR_004939467.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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