Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nucks1provided by MGI
Official Full Name: nuclear casein kinase and cyclin-dependent kinase substrate 1provided by MGI
Primary source: MGI:MGI:1934811
See related: Ensembl:ENSMUSG00000026434 AllianceGenome:MGI:1934811
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nucks; 2700010L10Rik; 8430423A01Rik
Summary: Predicted to enable DNA binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including cellular glucose homeostasis; positive regulation of transcription by RNA polymerase II; and regulation of insulin receptor signaling pathway. Acts upstream of or within glucose homeostasis and positive regulation of insulin receptor signaling pathway. Located in chromatin; cytoplasm; and nucleus. Is expressed in central nervous system; embryo; liver; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 35.6), limb E14.5 (RPKM 23.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.22 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131838196..131864059)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131910458..131936321)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer.
Title: CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer.
Study describes the role of NUCKS in corneal wound healing, inflammation and angiogenesis and links NUCKS to the activation of NF-kappa B and modulation of various cytokines.
Title: Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn.
in the context of Trp53 deficiency, wild type levels of Nucks1 are required to suppress radiation-induced thymic lymphoma, likely through the role of the NUCKS1 protein in the DNA damage response
Title: Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice.
This study demonstrates that depletion of NUCKS enhances the therapeutic efficacy of Bone marrow-derived mesenchymal stem cells for myocardial infarction via regulating the secretion of VEGFa.
Title: Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection.
Hypothalamic NUCKS plays an essential role in regulating glucose homoeostasis and insulin signaling.
Title: Hypothalamic NUCKS regulates peripheral glucose homoeostasis.
NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators.
Title: NUCKS is a positive transcriptional regulator of insulin signaling.
Results show that Nucks expression increased during the initial stages of embryonic development, and then gradually decreased until birth in all tissues except the nervous tissue and muscle fibers.
Title: Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development.
The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis.
Title: Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI647518 (e-PCR)
- UniSTS:178463

RH143279 (e-PCR)
- UniSTS:232526

35.MMHAP31FLD5.seq (e-PCR)
- UniSTS:158850

RH139043 (e-PCR)
- UniSTS:221129

RH126361 (e-PCR)
- UniSTS:163069

D1S2379 (e-PCR)
- UniSTS:6910

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cellular response to X-ray	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
involved_in intracellular glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation by host of RNA binding by virus	ISO Inferred from Sequence Orthology more info
involved_in modulation by host of viral RNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in modulation by host of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation by host of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA strand elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IC Inferred by Curator more info	PubMed
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Names: JC7; nuclear ubiquitous casein and cyclin-dependent kinases substrate; nuclear, casein kinase and cyclin-dependent kinase substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145804.1 → NP_001139276.1 nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of a coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is one aa shorter compared to isoform 1.

Source sequence(s)

AB049825, AC115001, AC161805, AK078816, CJ075701

Consensus CDS

CCDS78678.1

UniProtKB/TrEMBL

A0A087WRY3

Related

ENSMUSP00000140818.2, ENSMUST00000189946.7
NM_175294.3 → NP_780503.2 nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 1

See identical proteins and their annotated locations for NP_780503.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB049825, AC115001, AC161805, CJ075701

Consensus CDS

CCDS48356.1

UniProtKB/Swiss-Prot

Q80XU3, Q8BVD8

Related

ENSMUSP00000062576.7, ENSMUST00000062264.8