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    Car14 carbonic anhydrase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 791259, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Car14provided by RGD
    Official Full Name
    carbonic anhydrase 14provided by RGD
    Primary source
    RGD:1599277
    See related
    Ensembl:ENSRNOG00000023162 AllianceGenome:RGD:1599277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ca14
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human CA14 (carbonic anhydrase 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 233.9), Muscle (RPKM 182.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186131196..186138164, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183442263..183449231, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198010142..198017635, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene circadian associated repressor of transcription Neighboring gene similar to human chromosome 1 open reading frame 54 Neighboring gene aph-1 homolog A, gamma secretase subunit Neighboring gene small nucleolar RNA SNORA48 Neighboring gene acidic nuclear phosphoprotein 32 family member E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum. Akiba Y, et al. Gastroenterology, 2006 Jul. PMID 16831598
    2. Region- and cell-specific differences in the distribution of carbonic anhydrases II, III, XII, and XIV in the adult rat epididymis. Hermo L, et al. J Histochem Cytochem, 2005 Jun. PMID 15928319
    3. Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney. Kyllönen MS, et al. J Histochem Cytochem, 2003 Sep. PMID 12923247
    4. Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes. Whittington DA, et al. J Biol Chem, 2004 Feb 20. PMID 14660577
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 14
    Names
    carbonic anhydrase XIV
    NP_001103125.1
    XP_006233052.1
    XP_038959119.1
    XP_063138677.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109655.3 → NP_001103125.1  carbonic anhydrase 14 precursor

      See identical proteins and their annotated locations for NP_001103125.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GAJ9, A2IBE0
      Related
      ENSRNOP00000025523.6, ENSRNOT00000025523.7
      Conserved Domains (1) summary
      cd03126
      Location:29 → 278
      alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186131196..186138164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103191.1 → XP_038959119.1  carbonic anhydrase 14 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8W4
      Conserved Domains (1) summary
      cd03126
      Location:20 → 269
      alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...

    2. XM_006232990.4 → XP_006233052.1  carbonic anhydrase 14 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8W4
      Related
      ENSRNOP00000087858.1, ENSRNOT00000105035.1
      Conserved Domains (1) summary
      cd03126
      Location:20 → 269
      alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...

    3. XM_063282607.1 → XP_063138677.1  carbonic anhydrase 14 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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