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    Pcgf2 polycomb group ring finger 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287662, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pcgf2provided by RGD
    Official Full Name
    polycomb group ring finger 2provided by RGD
    Primary source
    RGD:1305097
    See related
    Ensembl:ENSRNOG00000012705 AllianceGenome:RGD:1305097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnf110
    Summary
    Predicted to enable promoter-specific chromatin binding activity. Predicted to be involved in heterochromatin assembly; histone H2A-K119 monoubiquitination; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cellular response to hydrogen peroxide; chordate embryonic development; and negative regulation of apoptotic signaling pathway. Predicted to be located in nuclear body and sex chromatin. Predicted to be part of PRC1 complex. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 30.1), Lung (RPKM 20.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83178926..83191610, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82682563..82694563, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85631829..85642591, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095289 Neighboring gene MLLT6, PHD finger containing Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene transfer RNA asparagine (anticodon GUU) 10 Neighboring gene proteasome 20S subunit beta 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and 36-kDa polypeptides. Yamaki M, et al. Gene, 2002 Apr 17. PMID 12034499
    2. BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Taherbhoy AM, et al. Nat Commun, 2015 Jul 7. PMID 26151332
    3. PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. Almeida M, et al. Science, 2017 Jun 9. PMID 28596365, Free PMC Article
    4. A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. Akasaka T, et al. Development, 1996 May. PMID 8625838
    5. A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. Negishi M, et al. PLoS One, 2010 Aug 24. PMID 20808772, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables ubiquitin-protein transferase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of sex chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polycomb group RING finger protein 2
    Names
    ring finger protein 110

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105836.2 → NP_001099306.1  polycomb group RING finger protein 2

      See identical proteins and their annotated locations for NP_001099306.1

      Status: PROVISIONAL

      Source sequence(s)
      BC167059
      UniProtKB/TrEMBL
      A6HIL6, A6HIL7, B2RZ82
      Related
      ENSRNOP00000017241.4, ENSRNOT00000017241.6
      Conserved Domains (3) summary
      PHA03247
      Location:222 → 304
      PHA03247; large tegument protein UL36; Provisional
      cd16736
      Location:12 → 65
      RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
      cd17164
      Location:130 → 228
      RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83178926..83191610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085606.2 → XP_038941534.1  polycomb group RING finger protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HIL6, A6HIL7, B2RZ82
      Conserved Domains (3) summary
      PHA03247
      Location:222 → 304
      PHA03247; large tegument protein UL36; Provisional
      cd16736
      Location:12 → 65
      RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
      cd17164
      Location:130 → 228
      RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

    2. XM_008767971.3 → XP_008766193.1  polycomb group RING finger protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008766193.1

      UniProtKB/TrEMBL
      A6HIL6, A6HIL7, B2RZ82
      Conserved Domains (3) summary
      PHA03247
      Location:222 → 304
      PHA03247; large tegument protein UL36; Provisional
      cd16736
      Location:12 → 65
      RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
      cd17164
      Location:130 → 228
      RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

    3. XM_008767972.3 → XP_008766194.1  polycomb group RING finger protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008766194.1

      UniProtKB/TrEMBL
      A6HIL6, A6HIL7, B2RZ82
      Conserved Domains (3) summary
      PHA03247
      Location:222 → 304
      PHA03247; large tegument protein UL36; Provisional
      cd16736
      Location:12 → 65
      RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
      cd17164
      Location:130 → 228
      RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

    4. XM_008767973.4 → XP_008766195.1  polycomb group RING finger protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008766195.1

      UniProtKB/TrEMBL
      A6HIL6, A6HIL7, B2RZ82
      Conserved Domains (3) summary
      PHA03247
      Location:222 → 304
      PHA03247; large tegument protein UL36; Provisional
      cd16736
      Location:12 → 65
      RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
      cd17164
      Location:130 → 228
      RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
    Nucleotide Protein Strain
    Heading Accession and Version

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