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    Icam4 intercellular adhesion molecule 4, Landsteiner-Wiener blood group [ Mus musculus (house mouse) ]

    Gene ID: 78369, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Icam4provided by MGI
    Official Full Name
    intercellular adhesion molecule 4, Landsteiner-Wiener blood groupprovided by MGI
    Primary source
    MGI:MGI:1925619
    See related
    Ensembl:ENSMUSG00000001014 AllianceGenome:MGI:1925619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd242; ICAM-4; 1810015M19Rik
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Located in cytoplasm; extracellular space; and plasma membrane. Orthologous to human ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14.5 (RPKM 38.0), liver E14 (RPKM 34.3) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A3; 9 7.69 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20940728..20941892)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21029432..21030596)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene STARR-seq mESC enhancer starr_23474 Neighboring gene STARR-seq mESC enhancer starr_23475 Neighboring gene intercellular adhesion molecule 1 Neighboring gene STARR-seq mESC enhancer starr_23476 Neighboring gene STARR-positive B cell enhancer ABC_E569 Neighboring gene STARR-positive B cell enhancer ABC_E10536 Neighboring gene microRNA 1900 Neighboring gene intercellular adhesion molecule 5, telencephalin Neighboring gene predicted gene, 26592

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation. Lee G, et al. Blood, 2006 Sep 15. PMID 16690966, Free PMC Article
    2. Novel secreted isoform of adhesion molecule ICAM-4: potential regulator of membrane-associated ICAM-4 interactions. Lee G, et al. Blood, 2003 Mar 1. PMID 12406883
    3. A transcriptional enhancer that directs telencephalon-specific transgene expression in mouse brain. Mitsui S, et al. Cereb Cortex, 2007 Mar. PMID 16581979
    4. ICAM-3, a ligand for DC-SIGN, was duplicated from ICAM-1 in mammalian evolution, but was lost in the rodent genome. Sugino H. FEBS Lett, 2005 May 23. PMID 15890347
    5. Comparative human-mouse-rat sequence analysis of the ICAM gene cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q. Leeb T, et al. Gene, 2004 Dec 22. PMID 15588578

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel second splice cDNA encodes an ICAM-4 isoform lacking the membrane-spanning domain. Erythroblasts express both isoforms. This new isoform, ICAM-4S, may modulate membrane-associated ICAM-4 binding & regulate erythroblast molecular attachments.
      Title: Novel secreted isoform of adhesion molecule ICAM-4: potential regulator of membrane-associated ICAM-4 interactions.
    2. ICAM-4 is critical in erythroblastic island formation via ICAM-4/alpha(V) adhesion
      Title: Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    intercellular adhesion molecule 4
    Names
    LW glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364509.1 → NP_001351438.1  intercellular adhesion molecule 4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC159314
      Consensus CDS
      CCDS90509.1
      Related
      ENSMUSP00000151013.2, ENSMUST00000215077.2
      Conserved Domains (2) summary
      pfam03921
      Location:40 → 123
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      cl28111
      Location:124 → 167
      Marek_A; Marek's disease glycoprotein A

    2. NM_023892.3 → NP_076381.1  intercellular adhesion molecule 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_076381.1

      Status: VALIDATED

      Source sequence(s)
      BC116909, D19050
      Consensus CDS
      CCDS22890.1
      UniProtKB/Swiss-Prot
      Q8K4L7, Q9CU00, Q9ERM2
      UniProtKB/TrEMBL
      Q14AB0
      Related
      ENSMUSP00000001040.6, ENSMUST00000001040.7
      Conserved Domains (2) summary
      PHA03271
      Location:124 → 167
      PHA03271; envelope glycoprotein C; Provisional
      pfam03921
      Location:40 → 123
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20940728..20941892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERM2.1 GenPept UniProtKB/Swiss-Prot:Q9ERM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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