Lgals3bp galectin 3 binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lgals3bpprovided by RGD
Official Full Name: galectin 3 binding proteinprovided by RGD
Primary source: RGD:620837
See related: Ensembl:ENSRNOG00000003217 AllianceGenome:RGD:620837
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mama; CyCAP; MAC2BP; Ppicap
Summary: Predicted to enable scavenger receptor activity. Predicted to be involved in cell adhesion and endocytosis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human LGALS3BP (galectin 3 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 309.8), Lung (RPKM 283.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (104118510..104127848, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (103619912..103629251, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (107415334..107424672, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CyCAP appears to control macrophage functions by activating NFAT and the resultant interleukin-2 production
Title: Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages.
Data give novel evidence that CyCAP regulates the post-translational modification of tissue transglutaminase through its colocalization with calnexin in endoplasmic reticulum.
Title: Cyclophilin C-associated protein/Mac-2 binding protein colocalizes with calnexin and regulates the expression of tissue transglutaminase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppicap (e-PCR), detects polymorphism
- UniSTS:144253

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galectin-3-binding protein

Names: 90K protein; cyp-C-associated protein; lectin galactoside-binding soluble 3-binding protein; mac-2 BP; mac-2-binding protein; peptidylprolyl isomerase C-associated protein; protein 90K

NP_620796.2

EC 3.6.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139096.2 → NP_620796.2 galectin-3-binding protein precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O70513, Q66HR4, Q6Q8R9

UniProtKB/TrEMBL

A0A8I6A7P6

Related

ENSRNOP00000004320.2, ENSRNOT00000004320.4

Conserved Domains (3) summary

smart00202
Location:24 → 124

SR; Scavenger receptor Cys-rich

cl38908
Location:136 → 247

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

cl28903
Location:256 → 329

BACK; BACK (BTB and C-terminal Kelch) domain