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    Svip small VCP/p97-interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 75744, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Svipprovided by MGI
    Official Full Name
    small VCP/p97-interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1922994
    See related
    Ensembl:ENSMUSG00000074093 AllianceGenome:MGI:1922994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700006C13Rik; 6620401M08Rik
    Summary
    Predicted to enable ATPase binding activity and protein self-association. Predicted to be involved in several processes, including negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly; negative regulation of retrograde protein transport, ER to cytosol; and regulation of cellular catabolic process. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Predicted to be active in endoplasmic reticulum membrane. Predicted to be anchored component of membrane. Orthologous to human SVIP (small VCP interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 18.1), cerebellum adult (RPKM 11.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Svip in Genome Data Viewer
    Location:
    7 B4; 7 32.91 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (51646909..51655766, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (51997161..52006018, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm683 Neighboring gene predicted gene, 33290 Neighboring gene Fanconi anemia, complementation group F Neighboring gene growth arrest specific 2 Neighboring gene STARR-seq mESC enhancer starr_18929 Neighboring gene STARR-seq mESC enhancer starr_18930 Neighboring gene STARR-positive B cell enhancer mm9_chr7:59261106-59261406 Neighboring gene coiled-coil domain containing 179 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP). Wu J, et al. Biochem Biophys Res Commun, 2013 Oct 11. PMID 24055875, Free PMC Article
    2. SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy. Wang Y, et al. PLoS One, 2011. PMID 21909394, Free PMC Article
    3. SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation. Nagahama M, et al. Mol Biol Cell, 2003 Jan. PMID 12529442, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SVIP and valosin containing protein were seen to be co-localized in neuronal cell bodies.
      Title: Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP).
    2. SVIP plays a regulatory role in p97 subcellular localization and is a novel regulator of autophagy.
      Title: SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein lipidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small VCP/p97-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160345.1 → NP_001153817.1  small VCP/p97-interacting protein

      See identical proteins and their annotated locations for NP_001153817.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein..
      Source sequence(s)
      AK158571, BX511488
      Consensus CDS
      CCDS57551.1
      UniProtKB/Swiss-Prot
      Q3UZP4
      Related
      ENSMUSP00000096014.4, ENSMUST00000098414.5
      Conserved Domains (1) summary
      pfam15811
      Location:1 → 71
      SVIP; Small VCP/p97-interacting protein

    RNA

    1. NR_027704.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the 5' coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC122017, AK005663, BX511488, BY089978

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      51646909..51655766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UZP4.1 GenPept UniProtKB/Swiss-Prot:Q3UZP4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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