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    Tube1 tubulin, epsilon 1 [ Mus musculus (house mouse) ]

    Gene ID: 71924, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tube1provided by MGI
    Official Full Name
    tubulin, epsilon 1provided by MGI
    Primary source
    MGI:MGI:1919174
    See related
    Ensembl:ENSMUSG00000019845 AllianceGenome:MGI:1919174
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tube; 2310061K05Rik
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including central nervous system; eye; and palatal shelf. Orthologous to human TUBE1 (tubulin epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 18.3), CNS E11.5 (RPKM 7.0) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B1; 10 20.16 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39009946..39035863)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39133949..39151058)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene laminin, alpha 4 Neighboring gene STARR-seq mESC enhancer starr_26379 Neighboring gene STARR-seq mESC enhancer starr_26383 Neighboring gene family with sequence similarity 229, member B Neighboring gene STARR-seq mESC enhancer starr_26384 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:38891010-38891195 Neighboring gene STARR-positive B cell enhancer ABC_E3883 Neighboring gene STARR-positive B cell enhancer ABC_E1797 Neighboring gene cellular communication network factor 6 Neighboring gene STARR-seq mESC enhancer starr_26386 Neighboring gene STARR-seq mESC enhancer starr_26387 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 31562

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pitx3 directly regulates Foxe3 during early lens development. Ahmad N, et al. Int J Dev Biol, 2013. PMID 24307298
    2. Keratin 13 deficiency causes white sponge nevus in mice. Simonson L, et al. Dev Biol, 2020 Dec 1. PMID 32758484, Free PMC Article
    3. TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Zhang L, et al. Mol Cell, 2013 Sep 12. PMID 23973329
    4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulin epsilon chain
    Names
    epsilon-tubulin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028006.2 → NP_082282.1  tubulin epsilon chain

      See identical proteins and their annotated locations for NP_082282.1

      Status: PROVISIONAL

      Source sequence(s)
      AK148039
      Consensus CDS
      CCDS23787.1
      UniProtKB/Swiss-Prot
      Q9D6T1
      Related
      ENSMUSP00000019991.8, ENSMUST00000019991.8
      Conserved Domains (1) summary
      cd02190
      Location:2 → 457
      epsilon_tubulin; The epsilon-tubulin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      39009946..39035863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156032.1 → XP_036011925.1  tubulin epsilon chain isoform X3

      Conserved Domains (1) summary
      cl10017
      Location:2 → 318
      Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like

    2. XM_036156030.1 → XP_036011923.1  tubulin epsilon chain isoform X1

      UniProtKB/Swiss-Prot
      Q9D6T1
      Conserved Domains (1) summary
      cd02190
      Location:2 → 457
      epsilon_tubulin; The epsilon-tubulin family

    3. XM_036156029.1 → XP_036011922.1  tubulin epsilon chain isoform X1

      UniProtKB/Swiss-Prot
      Q9D6T1
      Conserved Domains (1) summary
      cd02190
      Location:2 → 457
      epsilon_tubulin; The epsilon-tubulin family

    4. XM_036156031.1 → XP_036011924.1  tubulin epsilon chain isoform X1

      UniProtKB/Swiss-Prot
      Q9D6T1
      Conserved Domains (1) summary
      cd02190
      Location:2 → 457
      epsilon_tubulin; The epsilon-tubulin family

    5. XM_006512861.5 → XP_006512924.1  tubulin epsilon chain isoform X2

      See identical proteins and their annotated locations for XP_006512924.1

      Conserved Domains (1) summary
      cd02190
      Location:1 → 382
      epsilon_tubulin; The epsilon-tubulin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6T1.1 GenPept UniProtKB/Swiss-Prot:Q9D6T1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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