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    Exoc3l4 exocyst complex component 3-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 74190, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Exoc3l4provided by MGI
    Official Full Name
    exocyst complex component 3-like 4provided by MGI
    Primary source
    MGI:MGI:1921363
    See related
    Ensembl:ENSMUSG00000021280 AllianceGenome:MGI:1921363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200009I06Rik; 1600013K19Rik
    Summary
    Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization and exocytosis. Predicted to be part of exocyst. Orthologous to human EXOC3L4 (exocyst complex component 3 like 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 80.1), small intestine adult (RPKM 54.4) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 F1; 12 60.98 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111383864..111398114)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111417430..111431680)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230087F16 gene Neighboring gene CDC42 binding protein kinase beta Neighboring gene LBH domain containing 2 Neighboring gene tumor necrosis factor, alpha-induced protein 2 Neighboring gene predicted gene, 40578 Neighboring gene predicted gene 266

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocyst localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    exocyst complex component 3-like protein 4
    Names
    SEC6-like protein C14orf73 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289487.1 → NP_001276416.1  exocyst complex component 3-like protein 4

      See identical proteins and their annotated locations for NP_001276416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC122190, AK004674, BC075664, BM247872, BQ032492, BY235568, BY701311
      Consensus CDS
      CCDS26177.1
      UniProtKB/Swiss-Prot
      Q6DIA2, Q80UY5, Q9DAX8
      UniProtKB/TrEMBL
      A0A0R4J0W9
      Conserved Domains (1) summary
      pfam06046
      Location:182 → 708
      Sec6; Exocyst complex component Sec6

    2. NM_001289488.1 → NP_001276417.1  exocyst complex component 3-like protein 4

      See identical proteins and their annotated locations for NP_001276417.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK004674, BQ032492, BY701311, CF915432
      Consensus CDS
      CCDS26177.1
      UniProtKB/Swiss-Prot
      Q6DIA2, Q80UY5, Q9DAX8
      UniProtKB/TrEMBL
      A0A0R4J0W9
      Related
      ENSMUSP00000072438.7, ENSMUST00000072646.8
      Conserved Domains (1) summary
      pfam06046
      Location:182 → 708
      Sec6; Exocyst complex component Sec6

    3. NM_001289489.1 → NP_001276418.1  exocyst complex component 3-like protein 4

      See identical proteins and their annotated locations for NP_001276418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC122190
      Consensus CDS
      CCDS26177.1
      UniProtKB/Swiss-Prot
      Q6DIA2, Q80UY5, Q9DAX8
      UniProtKB/TrEMBL
      A0A0R4J0W9
      Related
      ENSMUSP00000152844.2, ENSMUST00000222897.2
      Conserved Domains (1) summary
      pfam06046
      Location:182 → 708
      Sec6; Exocyst complex component Sec6

    4. NM_028807.4 → NP_083083.3  exocyst complex component 3-like protein 4

      See identical proteins and their annotated locations for NP_083083.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK004674, BC075664, BQ032492, BY205345, BY701311
      Consensus CDS
      CCDS26177.1
      UniProtKB/Swiss-Prot
      Q6DIA2, Q80UY5, Q9DAX8
      UniProtKB/TrEMBL
      A0A0R4J0W9
      Related
      ENSMUSP00000152337.2, ENSMUST00000223050.2
      Conserved Domains (1) summary
      pfam06046
      Location:182 → 708
      Sec6; Exocyst complex component Sec6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111383864..111398114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516289.2 → XP_006516352.1  exocyst complex component 3-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006516352.1

      UniProtKB/Swiss-Prot
      Q6DIA2, Q80UY5, Q9DAX8
      UniProtKB/TrEMBL
      A0A0R4J0W9
      Conserved Domains (1) summary
      pfam06046
      Location:182 → 708
      Sec6; Exocyst complex component Sec6

    2. XM_006516291.5 → XP_006516354.1  exocyst complex component 3-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006516354.1

      UniProtKB/Swiss-Prot
      Q6DIA2, Q80UY5, Q9DAX8
      UniProtKB/TrEMBL
      A0A0R4J0W9
      Conserved Domains (1) summary
      pfam06046
      Location:182 → 708
      Sec6; Exocyst complex component Sec6

    3. XM_006516292.5 → XP_006516355.1  exocyst complex component 3-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006516355.1

      UniProtKB/Swiss-Prot
      Q6DIA2, Q80UY5, Q9DAX8
      UniProtKB/TrEMBL
      A0A0R4J0W9
      Conserved Domains (1) summary
      pfam06046
      Location:182 → 708
      Sec6; Exocyst complex component Sec6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DIA2.2 GenPept UniProtKB/Swiss-Prot:Q6DIA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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