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    Pde3b phosphodiesterase 3B, cGMP-inhibited [ Mus musculus (house mouse) ]

    Gene ID: 18576, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Pde3bprovided by MGI
    Official Full Name
    phosphodiesterase 3B, cGMP-inhibitedprovided by MGI
    Primary source
    MGI:MGI:1333863
    See related
    Ensembl:ENSMUSG00000030671 AllianceGenome:MGI:1333863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830102A01Rik
    Summary
    Enables protein kinase B binding activity. Acts upstream of or within several processes, including cellular response to insulin stimulus; glucose homeostasis; and regulation of insulin secretion. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE3B (phosphodiesterase 3B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 10.0), adrenal adult (RPKM 8.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F1; 7 59.46 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (114014388..114137173)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114415222..114537938)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4966 Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121419678-121419787 Neighboring gene STARR-positive B cell enhancer ABC_E9299 Neighboring gene STARR-positive B cell enhancer ABC_E10466 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121444899-121445200 Neighboring gene proteasome subunit alpha 1 Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121461019-121461282 Neighboring gene STARR-positive B cell enhancer ABC_E11365 Neighboring gene STARR-seq mESC enhancer starr_19927 Neighboring gene STARR-positive B cell enhancer ABC_E3745 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121575722-121576022 Neighboring gene STARR-positive B cell enhancer ABC_E8203 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121623448-121623749 Neighboring gene STARR-positive B cell enhancer ABC_E9702 Neighboring gene STARR-seq mESC enhancer starr_19929 Neighboring gene STARR-seq mESC enhancer starr_19930 Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_19932 Neighboring gene calcitonin/calcitonin-related polypeptide, alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function. Chung YW, et al. Sci Rep, 2017 Jan 13. PMID 28084425, Free PMC Article
    2. Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice. Sahu M, et al. Neuroendocrinology, 2017. PMID 27002827, Free PMC Article
    3. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. DiPilato LM, et al. Mol Cell Biol, 2015 Aug. PMID 26031333, Free PMC Article
    4. A role for phosphodiesterase 3B in acquisition of brown fat characteristics by white adipose tissue in male mice. Guirguis E, et al. Endocrinology, 2013 Sep. PMID 23766131, Free PMC Article
    5. Differences in phosphodiesterase 3A and 3B expression after ischemic insult. Mitome-Mishima Y, et al. Neurosci Res, 2013 Apr. PMID 23471014

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic actions of PKA in human and murine endothelial cells.
      Title: Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic actions of PKA in human and murine endothelial cells.
    2. whole-body ablation of PDE3A, but not PDE3B, provided similar protection against TAC-induced adverse ventricular remodeling
      Title: Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.
    3. microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance.
      Title: microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance.
    4. ABHD15 associates with and stabilizes phosphodiesterase 3B (PDE3B).
      Title: Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.
    5. Study demonstrated the presence of PDE3 protein and mRNA in human and murine airway tissues and concluded that PDE3A or PDE3B deficiency or pharmacological inhibition of PDE3 may alleviate the symptoms of allergic airway inflammation in a house dust mite-driven allergic airway inflammation mouse model.
      Title: A pathophysiological role of PDE3 in allergic airway inflammation.
    6. PDE3B and/or its downstream signaling partners might be important regulators of energy metabolism in adipose tissue.
      Title: White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function.
    7. NLRP3 inflammasome-mediated increase of IL1beta , TNFalpha and IL12-p40 in response to Lipopolysaccharides-associated danger signals participate in the development of proinflammatory state, leading to insulin resistance.
      Title: Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue.
    8. Study concludes that CUGBP1 is a critical regulator of insulin secretion via activating PDE3B.
      Title: RNA-binding protein CUGBP1 regulates insulin secretion via activation of phosphodiesterase 3B in mice.
    9. Insulin induction of hypothalamic phosphodiesterase 3B activity and the reversal of the anorectic and body weight-reducing effects and stimulatory effect of insulin on hypothalamic proopiomelanocortin gene expression by cilostamide suggest that activation of phosphodiesterase 3B is a novel mechanism of insulin signaling in the hypothalamus.
      Title: Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice.
    10. These results suggest the possibility for a direct role for the PDE3B pathway in mediating leptin action in the hypothalamus.
      Title: Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within endocrine pancreas development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
    Names
    CGI-PDE B
    CGIPDE1
    cGMP-inhibited 3',5'-cyclic phosphodiesterase B
    cyclic GMP-inhibited phosphodiesterase B
    NP_035185.2
    XP_006507501.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011055.2 → NP_035185.2  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

      Status: VALIDATED

      Source sequence(s)
      AJ132271, AK142889, AV270888, BB627812, BB663310, BU613166, BY745829, CJ058099, CJ299201
      Consensus CDS
      CCDS21760.1
      UniProtKB/Swiss-Prot
      Q61409, Q8CIX5, Q9Z1J9
      UniProtKB/TrEMBL
      E9QLQ3
      Related
      ENSMUSP00000032909.9, ENSMUST00000032909.9
      Conserved Domains (2) summary
      pfam00233
      Location:712 → 986
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam06532
      Location:60 → 241
      DUF1109; Protein of unknown function (DUF1109)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      114014388..114137173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507438.5 → XP_006507501.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1

      UniProtKB/Swiss-Prot
      Q61409, Q8CIX5, Q9Z1J9
      Conserved Domains (2) summary
      pfam00233
      Location:695 → 969
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam10101
      Location:116 → 260
      DUF2339; Predicted membrane protein (DUF2339)

    RNA

    1. XR_001785490.3 RNA Sequence

    2. XR_003946416.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61409.2 GenPept UniProtKB/Swiss-Prot:Q61409

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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