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    Mfsd6 major facilitator superfamily domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 98682, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mfsd6provided by MGI
    Official Full Name
    major facilitator superfamily domain containing 6provided by MGI
    Primary source
    MGI:MGI:1922925
    See related
    Ensembl:ENSMUSG00000041439 AllianceGenome:MGI:1922925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MMR2; 2210010L05Rik; 9630025I22Rik
    Summary
    Enables MHC class I protein binding activity and MHC class I receptor activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class I. Located in plasma membrane. Orthologous to human MFSD6 (major facilitator superfamily domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 15.1), cerebellum adult (RPKM 7.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mfsd6 in Genome Data Viewer
    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52695463..52766495, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52656286..52727358, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00902 Neighboring gene STARR-seq mESC enhancer starr_00903 Neighboring gene predicted gene 5527 Neighboring gene STARR-positive B cell enhancer ABC_E5753 Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene STARR-seq mESC enhancer starr_00904 Neighboring gene STARR-positive B cell enhancer ABC_E3274 Neighboring gene STARR-positive B cell enhancer ABC_E1543 Neighboring gene inositol polyphosphate-1-phosphatase Neighboring gene STARR-positive B cell enhancer ABC_E3275 Neighboring gene 3-hydroxyisobutyryl-Coenzyme A hydrolase Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Macrophage MHC and T-cell receptors essential for rejection of allografted skin and lymphoma. Tashiro-Yamaji J, et al. Transplantation, 2013 Aug 15. PMID 23836286
    2. HLA-B62 as a possible ligand for the human homologue of mouse macrophage MHC receptor 2 (MMR2) on monocytes. Shimizu T, et al. Gene, 2010 Apr 1. PMID 20123006
    3. Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption. Bagchi S, et al. Int J Neurosci, 2020 May. PMID 31906755
    4. Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice. Tashiro-Yamaji J, et al. Gene, 2006 Dec 15. PMID 17010536
    5. NOVA2 regulates neural circRNA biogenesis. Knupp D, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34157123, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption.
      Title: Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption.
    2. MMRs on monocytes/macrophages and TCRs on cytotoxic T lymphocytes in mice were essential for recognition and rejection of allografted skin and lymphoma, respectively.
      Title: Macrophage MHC and T-cell receptors essential for rejection of allografted skin and lymphoma.
    3. isolation of a cDNA clone encoding a novel receptor (MMR2) on allograft (H-2D(d)K(d))-induced macrophages (AIM) recognizing another MHC class I molecule, H-2K(d), by the expression cloning method
      Title: Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class I protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables MHC class I receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major facilitator superfamily domain-containing protein 6
    Names
    macrophage MHC class I receptor 2
    macrophage MHC receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357464.2 → NP_001344393.1  major facilitator superfamily domain-containing protein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139299, AC161876
      Conserved Domains (1) summary
      cd17335
      Location:71 → 625
      MFS_MFSD6; Major facilitator superfamily domain-containing protein 6

    2. NM_001403607.1 → NP_001390536.1  major facilitator superfamily domain-containing protein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139299, AC161876

    3. NM_001403611.1 → NP_001390540.1  major facilitator superfamily domain-containing protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC139299, AC161876
      UniProtKB/TrEMBL
      D3Z183

    4. NM_133829.3 → NP_598590.2  major facilitator superfamily domain-containing protein 6 isoform 1

      See identical proteins and their annotated locations for NP_598590.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC139299, AC161876
      Consensus CDS
      CCDS14945.2
      UniProtKB/TrEMBL
      D3Z183
      Related
      ENSMUSP00000122881.2, ENSMUST00000156876.8
      Conserved Domains (2) summary
      PHA03381
      Location:666 → 779
      PHA03381; tegument protein VP22; Provisional
      cd17335
      Location:71 → 625
      MFS_MFSD6; Major facilitator superfamily domain-containing protein 6

    5. NM_178081.5 → NP_835182.1  major facilitator superfamily domain-containing protein 6 isoform 2

      See identical proteins and their annotated locations for NP_835182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC139299, AC161876
      Consensus CDS
      CCDS14946.1
      UniProtKB/Swiss-Prot
      Q8C8K4, Q8CBH5, Q8VIG4
      Related
      ENSMUSP00000084991.4, ENSMUST00000087701.4
      Conserved Domains (4) summary
      cd06174
      Location:453 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:453 → 651
      MFS_1; Major Facilitator Superfamily
      pfam12832
      Location:68 → 143
      MFS_1_like; MFS_1 like family
      pfam16038
      Location:366 → 395
      TMIE; TMIE protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      52695463..52766495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CBH5.1 GenPept UniProtKB/Swiss-Prot:Q8CBH5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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