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    Swip-1 Swiprosin-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35158, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Swip-1provided by FlyBase
    Official Full Name
    Swiprosin-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032731
    Locus tag
    Dmel_CG10641
    See related
    AllianceGenome:FB:FBgn0032731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10641; Dmel\CG10641; DSwip-1; efhd; efhd2; EFhd2; swip; swip1
    Summary
    Predicted to enable calcium ion binding activity. Involved in mesoderm development. Located in muscle tendon junction and plasma membrane. Is expressed in several structures, including adult cerebrum; embryonic/larval hemocyte; embryonic/larval pharynx; extended germ band embryo; and muscle system. Orthologous to human EFHD1 (EF-hand domain family member D1) and EFHD2 (EF-hand domain family member D2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    37B8-37B8; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18977519..18987280, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18977519..18987280, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Numb-associated kinase Neighboring gene Transport and Golgi organization 6 Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ER membrane protein complex subunit 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure. Lehne F, et al. Nat Commun, 2022 May 6. PMID 35524157, Free PMC Article
    2. Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous EF-hand containing calcium binding adaptor proteins with distinct functions. Dütting S, et al. Cell Commun Signal, 2011 Jan 18. PMID 21244694, Free PMC Article
    3. Swip-1 promotes exocytosis of glue granules in the exocrine Drosophila salivary gland. Lehne F, et al. J Cell Sci, 2023 Mar 15. PMID 36727484, Free PMC Article
    4. The syncytial visceral and somatic musculature develops independently of β3-Tubulin during Drosophila embryogenesis, while maternally supplied β1-Tubulin is stable until the early steps of myoblast fusion. Rudolf A, et al. Eur J Cell Biol, 2012 Mar. PMID 22306378
    5. Simplified Insertion of Transgenes Onto Balancer Chromosomes via Recombinase-Mediated Cassette Exchange. Sun FF, et al. G3 (Bethesda), 2012 May. PMID 22670225, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Swip-1 promotes exocytosis of glue granules in the exocrine Drosophila salivary gland.
      Title: Swip-1 promotes exocytosis of glue granules in the exocrine Drosophila salivary gland.
    2. Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure.
      Title: Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure.
    3. Drosophila Swip-1 (CG10641), a homologue of human EFHD2 protein, participates in the breakdown of the prefusion complex during the progression of myoblast fusion
      Title: Drosophila Swiprosin-1/EFHD2 accumulates at the prefusion complex stage during Drosophila myoblast fusion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in muscle tendon junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Swiprosin-1
    Names
    CG10641-PA
    CG10641-PB
    EF-hand domain containing 2
    Swip-1-PA
    Swip-1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18977519..18987280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299150.1 → NP_001286079.1  Swiprosin-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286079.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJ26
      UniProtKB/TrEMBL
      X2J6X1
      Conserved Domains (1) summary
      cd00051
      Location:73 → 131
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_136081.3 → NP_609925.1  Swiprosin-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VJ26
      UniProtKB/TrEMBL
      X2J6X1
      Related
      FBpp0080727
      Conserved Domains (1) summary
      cd00051
      Location:73 → 131
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ26.1 Q9VJ26
    X2J6X1 X2J6X1

    Gene LinkOut

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