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    Usp14 Ubiquitin specific protease 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34387, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Usp14provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0032216
    Locus tag
    Dmel_CG5384
    See related
    AllianceGenome:FB:FBgn0032216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5384; Dmel\CG5384; DmUsp14; Q9VKZ8; Ubp6p; usp14; USP14
    Summary
    Predicted to enable proteasome binding activity and thiol-dependent deubiquitinase. Involved in protein ubiquitination. Is expressed in adult head. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    31D4-31D5; 2-41 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10312265..10314396, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10312265..10314396, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cdk5 activator-like protein Neighboring gene lethal (2) SH0834 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Function of Drosophila USP14 in Endoplasmic Reticulum Stress and Retinal Degeneration in a Model for Autosomal Dominant Retinitis Pigmentosa. Park JE, et al. Biology (Basel), 2020 Oct 12. PMID 33053617, Free PMC Article
    2. Inactivation of USP14 Perturbs Ubiquitin Homeostasis and Delays the Cell Cycle in Mouse Embryonic Fibroblasts and in Fruit Fly Drosophila. Lee JH, et al. Cell Physiol Biochem, 2018. PMID 29763934
    3. Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster. Kovács L, et al. J Cell Sci, 2020 Jan 23. PMID 31974276
    4. USP14 inhibition corrects an in vivo model of impaired mitophagy. Chakraborty J, et al. EMBO Mol Med, 2018 Nov. PMID 30249595, Free PMC Article
    5. Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster. Lundberg LE, et al. Nucleic Acids Res, 2012 Jul. PMID 22434883, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster.
      Title: Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster.
    2. genetic and pharmacological inhibition of USP14 promotes mitophagy
      Title: USP14 inhibition corrects an in vivo model of impaired mitophagy.
    3. Knocking down USP14 in Drosophila resulted in delayed eye development associated with reduced mitotic activity.
      Title: Inactivation of USP14 Perturbs Ubiquitin Homeostasis and Delays the Cell Cycle in Mouse Embryonic Fibroblasts and in Fruit Fly Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin specific protease 14
    Names
    CG5384-PA
    CG5384-PB
    Usp14-PA
    Usp14-PB
    NP_001260321.1
    NP_609377.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10312265..10314396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273392.1 → NP_001260321.1  ubiquitin specific protease 14, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKZ8
      Conserved Domains (4) summary
      smart00213
      Location:4 → 73
      UBQ; Ubiquitin homologues
      cd02657
      Location:105 → 467
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00443
      Location:103 → 467
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00155
      Location:5 → 73
      UBQ; Ubiquitin-like proteins

    2. NM_135533.2 → NP_609377.1  ubiquitin specific protease 14, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609377.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKZ8
      Related
      FBpp0079650
      Conserved Domains (4) summary
      smart00213
      Location:4 → 73
      UBQ; Ubiquitin homologues
      cd02657
      Location:105 → 467
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00443
      Location:103 → 467
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00155
      Location:5 → 73
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKZ8 Q9VKZ8

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