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    cer crammer [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37229, updated on 26-Apr-2024

    Summary

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    Official Symbol
    cerprovided by FlyBase
    Official Full Name
    crammerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034443
    Locus tag
    Dmel_CG10460
    See related
    AllianceGenome:FB:FBgn0034443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CER; CG10460; Crammer; D/CTLA-2; Dmel\CG10460
    Summary
    Enables cysteine-type endopeptidase inhibitor activity. Involved in inhibition of cysteine-type endopeptidase activity; long-term memory; and short-term memory. Located in endomembrane system. Is expressed in adult head; embryonic/larval garland cell; and prothoracic gland. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    56D3-56D3; 2-89 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19396215..19396772, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15283720..15284277, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45925 Neighboring gene Succinate dehydrogenase, subunit A (flavoprotein) Neighboring gene antisense RNA:CR43430 Neighboring gene hu li tai shao Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Studies of inhibitory mechanisms of propeptide-like cysteine protease inhibitors. Nga BT, et al. Enzyme Res, 2014. PMID 25045530, Free PMC Article
    2. Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster. Tseng TS, et al. PLoS One, 2013. PMID 23349821, Free PMC Article
    3. Drosophila CTLA-2-like protein (D/CTLA-2) inhibits cysteine proteinase 1 (CP1), a cathepsin L-like enzyme. Deshapriya RM, et al. Zoolog Sci, 2007 Jan. PMID 17409713
    4. Short and long-lasting behavioral consequences of agonistic encounters between male Drosophila melanogaster. Trannoy S, et al. Proc Natl Acad Sci U S A, 2016 Apr 26. PMID 27071097, Free PMC Article
    5. To favor survival under food shortage, the brain disables costly memory. Plaçais PY, et al. Science, 2013 Jan 25. PMID 23349289

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alanine substitution of residues W9, Y12, F16, Y20, Y32, and W53 within the hydrophobic cores, and charged residues E8, R28, R29, and E67 in the salt bridges considerably decrease the ability of crammer to inhibit cathepsin B (CTSB).
      Title: Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster.
    2. first solution structure of propeptide-like protease inhibitor in its active form and examined in detail using a variety of spectroscopic methods the folding properties of crammer in order to delineate its biomolecular recognition of cathepsin
      Title: A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin.
    3. CTLA-2, implicated in intra- and extra-cellular digestive processes, functions by suppressing uncontrolled enzymatic activities of CP1.
      Title: Drosophila CTLA-2-like protein (D/CTLA-2) inhibits cysteine proteinase 1 (CP1), a cathepsin L-like enzyme.
    4. Cer might have a role in glia and the concentration of the Cer peptide is critical for long term memory
      Title: Drosophila long-term memory formation involves regulation of cathepsin activity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in short-term memory IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in lysosome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    crammer
    Names
    CG10460-PA
    CTLA-2-like protein
    cer-PA
    drosophila CTLA-2like protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19396215..19396772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137576.4 → NP_611420.1  crammer [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611420.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBK7
      Related
      FBpp0085735
      Conserved Domains (1) summary
      pfam08246
      Location:9 → 68
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBK7 A1ZBK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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