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    Hap40 Huntingtin-associated protein 40 kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32507, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Hap40provided by FlyBase
    Official Full Name
    Huntingtin-associated protein 40 kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030671
    Locus tag
    Dmel_CG8134
    See related
    AllianceGenome:FB:FBgn0030671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg8134; CG8134; dhap40; Dmel\CG8134
    Summary
    Predicted to be involved in vesicle cytoskeletal trafficking. Predicted to be active in early endosome. Orthologous to human F8A3 (coagulation factor VIII associated 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    13E8-13E8; 1-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15704125..15705806)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15598158..15599839)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis. Xu S, et al. PLoS Genet, 2022 Jul. PMID 35853002, Free PMC Article
    2. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
    3. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
    5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein stabilization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in vesicle cytoskeletal trafficking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Huntingtin-associated protein 40 kDa
    Names
    CG8134-PA
    CG8134-PB
    Hap40-PA
    Hap40-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15704125..15705806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298354.1 → NP_001285283.1  Huntingtin-associated protein 40 kDa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXR6

    2. NM_132828.2 → NP_573056.1  Huntingtin-associated protein 40 kDa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXR6
      Related
      FBpp0073870
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXR6 Q9VXR6

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